“B” aware: Memory lane access is restricted!

Understanding the molecular mechanisms that govern the differentiation of high-affinity germinal center (GC) B cells into memory B cells versus plasma cells is a major quest of adaptive immunity. In this issue, Toboso-Navasa et al. (https://doi.org/10.1084/jem.20191933) provide evidence that the MYC...

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Detalles Bibliográficos
Autores principales: Kennedy, Ruth, Klein, Ulf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336317/
https://www.ncbi.nlm.nih.gov/pubmed/32516386
http://dx.doi.org/10.1084/jem.20200568
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author Kennedy, Ruth
Klein, Ulf
author_facet Kennedy, Ruth
Klein, Ulf
author_sort Kennedy, Ruth
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description Understanding the molecular mechanisms that govern the differentiation of high-affinity germinal center (GC) B cells into memory B cells versus plasma cells is a major quest of adaptive immunity. In this issue, Toboso-Navasa et al. (https://doi.org/10.1084/jem.20191933) provide evidence that the MYC–MIZ1 transcriptional repressor complex restricts the differentiation of GC B cells into MBCs.
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spelling pubmed-73363172021-01-06 “B” aware: Memory lane access is restricted! Kennedy, Ruth Klein, Ulf J Exp Med Insights Understanding the molecular mechanisms that govern the differentiation of high-affinity germinal center (GC) B cells into memory B cells versus plasma cells is a major quest of adaptive immunity. In this issue, Toboso-Navasa et al. (https://doi.org/10.1084/jem.20191933) provide evidence that the MYC–MIZ1 transcriptional repressor complex restricts the differentiation of GC B cells into MBCs. Rockefeller University Press 2020-06-09 /pmc/articles/PMC7336317/ /pubmed/32516386 http://dx.doi.org/10.1084/jem.20200568 Text en © 2020 Kennedy and Klein http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Kennedy, Ruth
Klein, Ulf
“B” aware: Memory lane access is restricted!
title “B” aware: Memory lane access is restricted!
title_full “B” aware: Memory lane access is restricted!
title_fullStr “B” aware: Memory lane access is restricted!
title_full_unstemmed “B” aware: Memory lane access is restricted!
title_short “B” aware: Memory lane access is restricted!
title_sort “b” aware: memory lane access is restricted!
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336317/
https://www.ncbi.nlm.nih.gov/pubmed/32516386
http://dx.doi.org/10.1084/jem.20200568
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