Targeting the innate immune receptor TLR8 using small-molecule agents

Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures...

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Detalles Bibliográficos
Autores principales: Sakaniwa, Kentaro, Shimizu, Toshiyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Isdsb2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336380/
https://www.ncbi.nlm.nih.gov/pubmed/32627735
http://dx.doi.org/10.1107/S2059798320006518
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author Sakaniwa, Kentaro
Shimizu, Toshiyuki
author_facet Sakaniwa, Kentaro
Shimizu, Toshiyuki
author_sort Sakaniwa, Kentaro
collection PubMed
description Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures of TLR8 complexed with various agonists or antagonists. Here, structural knowledge of the activation and inactivation mechanisms of the ligands is reviewed. In addition, the potential clinical applications of TLR ligands are examined.
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spelling pubmed-73363802020-07-17 Targeting the innate immune receptor TLR8 using small-molecule agents Sakaniwa, Kentaro Shimizu, Toshiyuki Acta Crystallogr D Struct Biol Isdsb2019 Toll-like receptors (TLRs) are pattern-recognition receptors that initiate innate immune responses. Among the TLRs, TLR8 (and TLR7) recognizes single-stranded RNA to mediate downstream signals. In recent years, intensive X-ray crystal structural analyses have provided atomic insights into structures of TLR8 complexed with various agonists or antagonists. Here, structural knowledge of the activation and inactivation mechanisms of the ligands is reviewed. In addition, the potential clinical applications of TLR ligands are examined. International Union of Crystallography 2020-06-17 /pmc/articles/PMC7336380/ /pubmed/32627735 http://dx.doi.org/10.1107/S2059798320006518 Text en © Sakaniwa & Shimizu 2020 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/
spellingShingle Isdsb2019
Sakaniwa, Kentaro
Shimizu, Toshiyuki
Targeting the innate immune receptor TLR8 using small-molecule agents
title Targeting the innate immune receptor TLR8 using small-molecule agents
title_full Targeting the innate immune receptor TLR8 using small-molecule agents
title_fullStr Targeting the innate immune receptor TLR8 using small-molecule agents
title_full_unstemmed Targeting the innate immune receptor TLR8 using small-molecule agents
title_short Targeting the innate immune receptor TLR8 using small-molecule agents
title_sort targeting the innate immune receptor tlr8 using small-molecule agents
topic Isdsb2019
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336380/
https://www.ncbi.nlm.nih.gov/pubmed/32627735
http://dx.doi.org/10.1107/S2059798320006518
work_keys_str_mv AT sakaniwakentaro targetingtheinnateimmunereceptortlr8usingsmallmoleculeagents
AT shimizutoshiyuki targetingtheinnateimmunereceptortlr8usingsmallmoleculeagents

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