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Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study

BACKGROUND: There is a positive association between raised resting heart rate (RHR), and all causes of mortality and shorter life expectancy. Several serum biomarkers and some anthropometric factors can affect the resting heart rate. This study aimed to investigate the determinants of resting heart...

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Autores principales: Goorakani, Yashar, Sedigh Rahimabadi, Massih, Dehghan, Azizallah, Kazemi, Maryam, Chijan, Mahsa Rostami, Bijani, Mostafa, Shahraki, Hadi Raeisi, Davoodi, Ali, Farjam, Mojtaba, Homayounfar, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336436/
https://www.ncbi.nlm.nih.gov/pubmed/32631242
http://dx.doi.org/10.1186/s12872-020-01594-y
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author Goorakani, Yashar
Sedigh Rahimabadi, Massih
Dehghan, Azizallah
Kazemi, Maryam
Chijan, Mahsa Rostami
Bijani, Mostafa
Shahraki, Hadi Raeisi
Davoodi, Ali
Farjam, Mojtaba
Homayounfar, Reza
author_facet Goorakani, Yashar
Sedigh Rahimabadi, Massih
Dehghan, Azizallah
Kazemi, Maryam
Chijan, Mahsa Rostami
Bijani, Mostafa
Shahraki, Hadi Raeisi
Davoodi, Ali
Farjam, Mojtaba
Homayounfar, Reza
author_sort Goorakani, Yashar
collection PubMed
description BACKGROUND: There is a positive association between raised resting heart rate (RHR), and all causes of mortality and shorter life expectancy. Several serum biomarkers and some anthropometric factors can affect the resting heart rate. This study aimed to investigate the determinants of resting heart rate in a large random sample of the Iranian population. MATERIAL AND METHODS: It is a standardized, retrospective study and the subjects were chosen from the baseline survey of the Prospective Epidemiological Research Study in IrAN (PERSIAN) Fasa non-communicable disease cohort study. It was conducted from winter 2014 to summer 2019 and after obtaining informed consent from a random sample, all the eligible subjects were enrolled. All anthropometric factors and biologic laboratory factors were collected and analyzed by implement smoothly clipped absolute deviation (SCAD) linear regression and SCAD quantile regression. The comparisons between males and females were done via independent T-test. RESULTS & CONCLUSION: A total number of 9975 persons from 35 to 90 years old were included. The overall median resting heart rate was 74 (interquartile range:66–80). Mean age has no important difference between males and females (P = 0.79) but, resting heart rate was significantly higher in females (76.6 versus 71.4, P < 0.001). All anthropometric factors except wrist circumference were higher in females (P < 0.05). Age has an adverse effect on resting heart rate and also, there was a direct association between resting heart rate and systolic blood pressure and blood glucose. Alpha-blockers (coefficient = 5.2) and Beta1-blockers (coefficient = − 2.2) were the most effective drugs with positive and negative effects on resting heart rate respectively. Lower hemoglobin, obesity, and more body mass index, and more low-density lipoprotein were associated with more resting heart rate. Continuing the monitoring of this sample via our cohort study and put to action multinational prospective researches with large sample sizes and long follow-ups can lead to more precise results and better scientific judgments.
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spelling pubmed-73364362020-07-07 Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study Goorakani, Yashar Sedigh Rahimabadi, Massih Dehghan, Azizallah Kazemi, Maryam Chijan, Mahsa Rostami Bijani, Mostafa Shahraki, Hadi Raeisi Davoodi, Ali Farjam, Mojtaba Homayounfar, Reza BMC Cardiovasc Disord Research Article BACKGROUND: There is a positive association between raised resting heart rate (RHR), and all causes of mortality and shorter life expectancy. Several serum biomarkers and some anthropometric factors can affect the resting heart rate. This study aimed to investigate the determinants of resting heart rate in a large random sample of the Iranian population. MATERIAL AND METHODS: It is a standardized, retrospective study and the subjects were chosen from the baseline survey of the Prospective Epidemiological Research Study in IrAN (PERSIAN) Fasa non-communicable disease cohort study. It was conducted from winter 2014 to summer 2019 and after obtaining informed consent from a random sample, all the eligible subjects were enrolled. All anthropometric factors and biologic laboratory factors were collected and analyzed by implement smoothly clipped absolute deviation (SCAD) linear regression and SCAD quantile regression. The comparisons between males and females were done via independent T-test. RESULTS & CONCLUSION: A total number of 9975 persons from 35 to 90 years old were included. The overall median resting heart rate was 74 (interquartile range:66–80). Mean age has no important difference between males and females (P = 0.79) but, resting heart rate was significantly higher in females (76.6 versus 71.4, P < 0.001). All anthropometric factors except wrist circumference were higher in females (P < 0.05). Age has an adverse effect on resting heart rate and also, there was a direct association between resting heart rate and systolic blood pressure and blood glucose. Alpha-blockers (coefficient = 5.2) and Beta1-blockers (coefficient = − 2.2) were the most effective drugs with positive and negative effects on resting heart rate respectively. Lower hemoglobin, obesity, and more body mass index, and more low-density lipoprotein were associated with more resting heart rate. Continuing the monitoring of this sample via our cohort study and put to action multinational prospective researches with large sample sizes and long follow-ups can lead to more precise results and better scientific judgments. BioMed Central 2020-07-06 /pmc/articles/PMC7336436/ /pubmed/32631242 http://dx.doi.org/10.1186/s12872-020-01594-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Goorakani, Yashar
Sedigh Rahimabadi, Massih
Dehghan, Azizallah
Kazemi, Maryam
Chijan, Mahsa Rostami
Bijani, Mostafa
Shahraki, Hadi Raeisi
Davoodi, Ali
Farjam, Mojtaba
Homayounfar, Reza
Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study
title Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study
title_full Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study
title_fullStr Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study
title_full_unstemmed Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study
title_short Correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: Fasa PERSIAN cohort study
title_sort correlation of resting heart rate with anthropometric factors and serum biomarkers in a population-based study: fasa persian cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336436/
https://www.ncbi.nlm.nih.gov/pubmed/32631242
http://dx.doi.org/10.1186/s12872-020-01594-y
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