COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms

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SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both m...

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Autores principales: Malone, Robert W., Tisdall, Philip, Fremont-Smith, Philip, Liu, Yongfeng, Huang, Xi-Ping, White, Kris M., Miorin, Lisa, Del Olmo, Elena Moreno, Alon, Assaf, Delaforge, Elise, Hennecker, Christopher D., Wang, Guanyu, Pottel, Joshua, Smith, Nora, Hall, Julie M., Shapiro, Gideon, Mittermaier, Anthony, Kruse, Andrew C., García-Sastre, Adolfo, Roth, Bryan L., Glasspool-Malone, Jill, Ricke, Darrell O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336703/
https://www.ncbi.nlm.nih.gov/pubmed/32702719
http://dx.doi.org/10.21203/rs.3.rs-30934/v3
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author Malone, Robert W.
Tisdall, Philip
Fremont-Smith, Philip
Liu, Yongfeng
Huang, Xi-Ping
White, Kris M.
Miorin, Lisa
Del Olmo, Elena Moreno
Alon, Assaf
Delaforge, Elise
Hennecker, Christopher D.
Wang, Guanyu
Pottel, Joshua
Smith, Nora
Hall, Julie M.
Shapiro, Gideon
Mittermaier, Anthony
Kruse, Andrew C.
García-Sastre, Adolfo
Roth, Bryan L.
Glasspool-Malone, Jill
Ricke, Darrell O.
author_facet Malone, Robert W.
Tisdall, Philip
Fremont-Smith, Philip
Liu, Yongfeng
Huang, Xi-Ping
White, Kris M.
Miorin, Lisa
Del Olmo, Elena Moreno
Alon, Assaf
Delaforge, Elise
Hennecker, Christopher D.
Wang, Guanyu
Pottel, Joshua
Smith, Nora
Hall, Julie M.
Shapiro, Gideon
Mittermaier, Anthony
Kruse, Andrew C.
García-Sastre, Adolfo
Roth, Bryan L.
Glasspool-Malone, Jill
Ricke, Darrell O.
author_sort Malone, Robert W.
collection PubMed
description SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We explore several plausible avenues of activity including antiviral and host-mediated actions. We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H(2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release.
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spelling pubmed-73367032020-07-14 COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms Malone, Robert W. Tisdall, Philip Fremont-Smith, Philip Liu, Yongfeng Huang, Xi-Ping White, Kris M. Miorin, Lisa Del Olmo, Elena Moreno Alon, Assaf Delaforge, Elise Hennecker, Christopher D. Wang, Guanyu Pottel, Joshua Smith, Nora Hall, Julie M. Shapiro, Gideon Mittermaier, Anthony Kruse, Andrew C. García-Sastre, Adolfo Roth, Bryan L. Glasspool-Malone, Jill Ricke, Darrell O. Res Sq Article SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. Currently, there are no pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We explore several plausible avenues of activity including antiviral and host-mediated actions. We propose that the principal famotidine mechanism of action for COVID-19 involves on-target histamine receptor H(2) activity, and that development of clinical COVID-19 involves dysfunctional mast cell activation and histamine release. American Journal Experts 2020-08-31 /pmc/articles/PMC7336703/ /pubmed/32702719 http://dx.doi.org/10.21203/rs.3.rs-30934/v3 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Malone, Robert W.
Tisdall, Philip
Fremont-Smith, Philip
Liu, Yongfeng
Huang, Xi-Ping
White, Kris M.
Miorin, Lisa
Del Olmo, Elena Moreno
Alon, Assaf
Delaforge, Elise
Hennecker, Christopher D.
Wang, Guanyu
Pottel, Joshua
Smith, Nora
Hall, Julie M.
Shapiro, Gideon
Mittermaier, Anthony
Kruse, Andrew C.
García-Sastre, Adolfo
Roth, Bryan L.
Glasspool-Malone, Jill
Ricke, Darrell O.
COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
title COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
title_full COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
title_fullStr COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
title_full_unstemmed COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
title_short COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
title_sort covid-19: famotidine, histamine, mast cells, and mechanisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336703/
https://www.ncbi.nlm.nih.gov/pubmed/32702719
http://dx.doi.org/10.21203/rs.3.rs-30934/v3
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