Crystallographic and spectroscopic characterization of racemic Mosher’s Acid

The title compound, C(10)H(9)F(3)O(3), represents the structure of racemic Mosher’s Acid (systematic name: 3,3,3-tri­fluoro-2-meth­oxy-2-phenyl­propanoic acid), a carb­oxy­lic acid that when resolved can be employed as a chiral derivatizing agent. The compound contains a carb­oxy­lic acid group, a m...

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Detalles Bibliográficos
Autores principales: Savich, Carolyn Z., Tanski, Joseph M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336789/
https://www.ncbi.nlm.nih.gov/pubmed/32695469
http://dx.doi.org/10.1107/S2056989020008403
Descripción
Sumario:The title compound, C(10)H(9)F(3)O(3), represents the structure of racemic Mosher’s Acid (systematic name: 3,3,3-tri­fluoro-2-meth­oxy-2-phenyl­propanoic acid), a carb­oxy­lic acid that when resolved can be employed as a chiral derivatizing agent. The compound contains a carb­oxy­lic acid group, a meth­oxy group and a tri­fluoro­methyl substituent on an asymmetric benzylic carbon atom. The two independent mol­ecules in the asymmetric unit form a non-centrosymmetric homochiral dimer via inter­molecularly hydrogen-bonded head-to-tail dimers with graph-set notation R (2) (2)(8) and donor–acceptor hydrogen-bonding distances of 2.6616 (13) and 2.6801 (13) Å.

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