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Crystallographic and spectroscopic characterization of racemic Mosher’s Acid
The title compound, C(10)H(9)F(3)O(3), represents the structure of racemic Mosher’s Acid (systematic name: 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid), a carboxylic acid that when resolved can be employed as a chiral derivatizing agent. The compound contains a carboxylic acid group, a m...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336789/ https://www.ncbi.nlm.nih.gov/pubmed/32695469 http://dx.doi.org/10.1107/S2056989020008403 |
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author | Savich, Carolyn Z. Tanski, Joseph M. |
author_facet | Savich, Carolyn Z. Tanski, Joseph M. |
author_sort | Savich, Carolyn Z. |
collection | PubMed |
description | The title compound, C(10)H(9)F(3)O(3), represents the structure of racemic Mosher’s Acid (systematic name: 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid), a carboxylic acid that when resolved can be employed as a chiral derivatizing agent. The compound contains a carboxylic acid group, a methoxy group and a trifluoromethyl substituent on an asymmetric benzylic carbon atom. The two independent molecules in the asymmetric unit form a non-centrosymmetric homochiral dimer via intermolecularly hydrogen-bonded head-to-tail dimers with graph-set notation R (2) (2)(8) and donor–acceptor hydrogen-bonding distances of 2.6616 (13) and 2.6801 (13) Å. |
format | Online Article Text |
id | pubmed-7336789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-73367892020-07-20 Crystallographic and spectroscopic characterization of racemic Mosher’s Acid Savich, Carolyn Z. Tanski, Joseph M. Acta Crystallogr E Crystallogr Commun Research Communications The title compound, C(10)H(9)F(3)O(3), represents the structure of racemic Mosher’s Acid (systematic name: 3,3,3-trifluoro-2-methoxy-2-phenylpropanoic acid), a carboxylic acid that when resolved can be employed as a chiral derivatizing agent. The compound contains a carboxylic acid group, a methoxy group and a trifluoromethyl substituent on an asymmetric benzylic carbon atom. The two independent molecules in the asymmetric unit form a non-centrosymmetric homochiral dimer via intermolecularly hydrogen-bonded head-to-tail dimers with graph-set notation R (2) (2)(8) and donor–acceptor hydrogen-bonding distances of 2.6616 (13) and 2.6801 (13) Å. International Union of Crystallography 2020-06-26 /pmc/articles/PMC7336789/ /pubmed/32695469 http://dx.doi.org/10.1107/S2056989020008403 Text en © Savich and Tanski 2020 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Research Communications Savich, Carolyn Z. Tanski, Joseph M. Crystallographic and spectroscopic characterization of racemic Mosher’s Acid |
title | Crystallographic and spectroscopic characterization of racemic Mosher’s Acid |
title_full | Crystallographic and spectroscopic characterization of racemic Mosher’s Acid |
title_fullStr | Crystallographic and spectroscopic characterization of racemic Mosher’s Acid |
title_full_unstemmed | Crystallographic and spectroscopic characterization of racemic Mosher’s Acid |
title_short | Crystallographic and spectroscopic characterization of racemic Mosher’s Acid |
title_sort | crystallographic and spectroscopic characterization of racemic mosher’s acid |
topic | Research Communications |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336789/ https://www.ncbi.nlm.nih.gov/pubmed/32695469 http://dx.doi.org/10.1107/S2056989020008403 |
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