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Structural basis for differentiation between two classes of thiolase: Degradative vs biosynthetic thiolase

Thiolases are a well characterized family of enzymes with two distinct categories: degradative, β-ketoadipyl-CoA thiolases and biosynthetic, acetoacetyl-CoA thiolases. Both classes share an identical catalytic triad but catalyze reactions in opposite directions. Moreover, it is established that in c...

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Detalles Bibliográficos
Autores principales: Bhaskar, Sukritee, Steer, David L., Anand, Ruchi, Panjikar, Santosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337054/
https://www.ncbi.nlm.nih.gov/pubmed/32647822
http://dx.doi.org/10.1016/j.yjsbx.2019.100018

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