The heterologous expression of Escherichia coli MutT enzyme is involved in the protection against oxidative stress in Leishmania braziliensis

BACKGROUND: Oxidative stress is responsible for generating DNA lesions and the 8-oxoguanine (8-oxoG) is the most commonly lesion found in DNA damage. When this base is incorporated during DNA replication, it could generate double-strand DNA breaks and cellular death. MutT enzyme hydrolyzes the 8-oxo...

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Detalles Bibliográficos
Autores principales: Andrade, Laila de Carvalho, Santi, Ana Maria Murta, Alves, Ceres Luciana, Ferreira, Wesley Roger Rodrigues, de Assis, Antônio Vinícius, Oliveira, Edward, Machado, Carlos Renato, Murta, Silvane Maria Fonseca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337112/
https://www.ncbi.nlm.nih.gov/pubmed/32638832
http://dx.doi.org/10.1590/0074-02760190469

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