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Apolipoprotein E ε-4 as a genetic determinant of Alzheimer’s disease heterogeneity

Alzheimer’s disease (AD) displays a high degree of heterogeneity in terms of its etiology, presentation, prognosis, and treatment response. This can partly be explained by high-penetrance mutations in the amyloid precursor protein, presenilin 1 and presenilin 2 genes causing amyloid beta aggregation...

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Detalles Bibliográficos
Autores principales:	Kotze, MJ, Lückhoff, HK, Brand, T, Pretorius, J, van Rensburg, SJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337157/ https://www.ncbi.nlm.nih.gov/pubmed/32669910 http://dx.doi.org/10.2147/DNND.S41721

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