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Critical analysis of the use of β-site amyloid precursor protein-cleaving enzyme 1 inhibitors in the treatment of Alzheimer’s disease
Alzheimer’s disease (AD) is the major cause of dementia in the elderly and an unmet clinical challenge. A variety of therapies that are currently under development are directed to the amyloid cascade. Indeed, the accumulation and toxicity of amyloid-β (Aβ) is believed to play a central role in the e...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337240/ https://www.ncbi.nlm.nih.gov/pubmed/32669897 http://dx.doi.org/10.2147/DNND.S41056 |