Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits

To efficiently transform genetic associations into drug targets requires evidence that a particular gene, and its encoded protein, contribute causally to a disease. To achieve this, we employ a three-step proteome-by-phenome Mendelian Randomization (MR) approach. In step one, 154 protein quantitativ...

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Detalles Bibliográficos
Autores principales: Bretherick, Andrew D., Canela-Xandri, Oriol, Joshi, Peter K., Clark, David W., Rawlik, Konrad, Boutin, Thibaud S., Zeng, Yanni, Amador, Carmen, Navarro, Pau, Rudan, Igor, Wright, Alan F., Campbell, Harry, Vitart, Veronique, Hayward, Caroline, Wilson, James F., Tenesa, Albert, Ponting, Chris P., Baillie, J. Kenneth, Haley, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337286/
https://www.ncbi.nlm.nih.gov/pubmed/32628676
http://dx.doi.org/10.1371/journal.pgen.1008785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337286/
https://www.ncbi.nlm.nih.gov/pubmed/32628676
http://dx.doi.org/10.1371/journal.pgen.1008785

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