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Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits
To efficiently transform genetic associations into drug targets requires evidence that a particular gene, and its encoded protein, contribute causally to a disease. To achieve this, we employ a three-step proteome-by-phenome Mendelian Randomization (MR) approach. In step one, 154 protein quantitativ...
Autores principales: | Bretherick, Andrew D., Canela-Xandri, Oriol, Joshi, Peter K., Clark, David W., Rawlik, Konrad, Boutin, Thibaud S., Zeng, Yanni, Amador, Carmen, Navarro, Pau, Rudan, Igor, Wright, Alan F., Campbell, Harry, Vitart, Veronique, Hayward, Caroline, Wilson, James F., Tenesa, Albert, Ponting, Chris P., Baillie, J. Kenneth, Haley, Chris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337286/ https://www.ncbi.nlm.nih.gov/pubmed/32628676 http://dx.doi.org/10.1371/journal.pgen.1008785 |
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