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Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant
The SARS-CoV-2 spike (S) protein variant D614G supplanted the ancestral virus worldwide in a matter of months. Here we show that D614G was more infectious than the ancestral form on human lung cells, colon cells, and cells rendered permissive by ectopic expression of various mammalian ACE2 orthologs...
Autores principales: | Yurkovetskiy, Leonid, Wang, Xue, Pascal, Kristen E., Tomkins-Tinch, Christopher, Nyalile, Thomas, Wang, Yetao, Baum, Alina, Diehl, William E., Dauphin, Ann, Carbone, Claudia, Veinotte, Kristen, Egri, Shawn B., Schaffner, Stephen F., Lemieux, Jacob E., Munro, James, Rafique, Ashique, Barve, Abhi, Sabeti, Pardis C., Kyratsous, Christos A., Dudkina, Natalya, Shen, Kuang, Luban, Jeremy |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337374/ https://www.ncbi.nlm.nih.gov/pubmed/32637944 http://dx.doi.org/10.1101/2020.07.04.187757 |
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