High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity

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A novel coronavirus (SARS-CoV-2) has emerged to a global pandemic and caused significant damages to public health. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2 cleaves many biological substrates besides Ang II to control...

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Detalles Bibliográficos
Autores principales: Lu, Jinghua, Sun, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337377/
https://www.ncbi.nlm.nih.gov/pubmed/32637947
http://dx.doi.org/10.1101/2020.07.01.182659

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