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Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition

PURPOSE: The mechanism of cardioprotection by Kv7.1–5 (KCNQ1-5) channels inhibition by XE991 is unclear. We examined the impact of administration time on the cardioprotective efficacy of XE991, the involvement of key pro-survival kinases, and the importance of the Kv7 subchannels. METHODS: Isolated...

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Detalles Bibliográficos
Autores principales:	Hansen, Jan, Johnsen, Jacob, Nielsen, Jan Møller, Sørensen, Charlotte Brandt, Elkjær, Casper Carlsen, Jespersen, Nichlas Riise, Bøtker, Hans Erik
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337438/ https://www.ncbi.nlm.nih.gov/pubmed/32669836 http://dx.doi.org/10.2147/DDDT.S226406

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