Mitochondrial DNA segregation and replication restrict the transmission of detrimental mutation

Although mitochondrial DNA (mtDNA) is prone to accumulate mutations and lacks conventional DNA repair mechanisms, deleterious mutations are exceedingly rare. How the transmission of detrimental mtDNA mutations is restricted through the maternal lineage is debated. Here, we demonstrate that mitochond...

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Detalles Bibliográficos
Autores principales: Chen, Zhe, Wang, Zong-Heng, Zhang, Guofeng, Bleck, Christopher K.E., Chung, Dillon J., Madison, Grey P., Lindberg, Eric, Combs, Christian, Balaban, Robert S., Xu, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337505/
https://www.ncbi.nlm.nih.gov/pubmed/32375181
http://dx.doi.org/10.1083/jcb.201905160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337505/
https://www.ncbi.nlm.nih.gov/pubmed/32375181
http://dx.doi.org/10.1083/jcb.201905160

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