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Stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

Membrane integrity at the endoplasmic reticulum (ER) is tightly regulated, and its disturbance is implicated in metabolic diseases. Using an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identified pathwa...

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Detalles Bibliográficos
Autores principales:	Ho, Nurulain, Yap, Wei Sheng, Xu, Jiaming, Wu, Haoxi, Koh, Jhee Hong, Goh, Wilson Wen Bin, George, Bhawana, Chong, Shu Chen, Taubert, Stefan, Thibault, Guillaume
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337508/ https://www.ncbi.nlm.nih.gov/pubmed/32349127 http://dx.doi.org/10.1083/jcb.201909165

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