Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

OGG1 initiated base excision repair (BER) is the major pathway for repair of oxidative DNA base damage 8-oxoguanine (8-oxoG). Here, we report that RECQL4 DNA helicase, deficient in the cancer-prone and premature aging Rothmund-Thomson syndrome, physically and functionally interacts with OGG1. RECQL4...

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Detalles Bibliográficos
Autores principales: Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, Deborah L, Rasmussen, Lene Juel, Bohr, Vilhelm A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337523/
https://www.ncbi.nlm.nih.gov/pubmed/32432680
http://dx.doi.org/10.1093/nar/gkaa392

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