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Mammalian Nudix proteins cleave nucleotide metabolite caps on RNAs

We recently reported the presence of nicotinamide adenine dinucleotide (NAD)-capped RNAs in mammalian cells and a role for DXO and the Nudix hydrolase Nudt12 in decapping NAD-capped RNAs (deNADding) in cells. Analysis of 5′caps has revealed that in addition to NAD, mammalian RNAs also contain other...

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Detalles Bibliográficos
Autores principales:	Sharma, Sunny, Grudzien-Nogalska, Ewa, Hamilton, Keith, Jiao, Xinfu, Yang, Jun, Tong, Liang, Kiledjian, Megerditch
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337524/ https://www.ncbi.nlm.nih.gov/pubmed/32432673 http://dx.doi.org/10.1093/nar/gkaa402

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