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Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway

BACKGROUND: Alterations in the levels of arginine and its related catabolic products (ie, ornithine, citrulline, and argininosuccinate) in the urea and nitric oxide cycles were reported to play roles in the pathogenesis of major depressive disorder (MDD). The aim of this meta-analysis study is to ex...

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Autores principales: Cao, Bing, Deng, Runze, Wang, Dongfang, Li, Li, Ren, Zhongyu, Xu, Lixin, Gao, Xiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337538/
https://www.ncbi.nlm.nih.gov/pubmed/32629736
http://dx.doi.org/10.1097/MD.0000000000021068
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author Cao, Bing
Deng, Runze
Wang, Dongfang
Li, Li
Ren, Zhongyu
Xu, Lixin
Gao, Xiao
author_facet Cao, Bing
Deng, Runze
Wang, Dongfang
Li, Li
Ren, Zhongyu
Xu, Lixin
Gao, Xiao
author_sort Cao, Bing
collection PubMed
description BACKGROUND: Alterations in the levels of arginine and its related catabolic products (ie, ornithine, citrulline, and argininosuccinate) in the urea and nitric oxide cycles were reported to play roles in the pathogenesis of major depressive disorder (MDD). The aim of this meta-analysis study is to explore the associations between arginine with its related catabolic products and MDD, and to discuss the possible role of arginine catabolism in the pathoetiology of MDD. METHODS: This study will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The English language literature published in the databases of PubMed, EMBASE, PsycINFO and Web of Science will be systematically searched. Forest plots will be used to estimate the associations between arginine and its related catabolic products with MDD. Subgroup analysis and meta-regression will also be performed to investigate the source of the potential heterogeneity. Sensitivity analysis will be performed to strengthen the results and to investigate whether any single study would have a significant effect on the results of meta-analysis. Publication bias will be tested for using the funnel plot with Begg test and Egger test. The Newcastle-Ottawa Scale will be applied to assess the risk of bias of observational studies. RESULTS: An integrated assessment of arginine with its related catabolic products may contribute to predict the risk of MDD. ETHICS AND DISSEMINATION: The results of associations between arginine with its related catabolic products and MDD will be reported in a peer-reviewed publication. With our findings from this meta-analysis, we hope to provide the most up-to-date evidence for the contributions of arginine and related catabolic products to predict the risk of MDD. SYSTEMATIC REVIEW REGISTRATION: The protocol of current meta-analysis has been registered at the Open Science Framework [Available at: https://doi.org/10.17605/osf.io/7fn59].
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spelling pubmed-73375382020-07-14 Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway Cao, Bing Deng, Runze Wang, Dongfang Li, Li Ren, Zhongyu Xu, Lixin Gao, Xiao Medicine (Baltimore) 5000 BACKGROUND: Alterations in the levels of arginine and its related catabolic products (ie, ornithine, citrulline, and argininosuccinate) in the urea and nitric oxide cycles were reported to play roles in the pathogenesis of major depressive disorder (MDD). The aim of this meta-analysis study is to explore the associations between arginine with its related catabolic products and MDD, and to discuss the possible role of arginine catabolism in the pathoetiology of MDD. METHODS: This study will be conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The English language literature published in the databases of PubMed, EMBASE, PsycINFO and Web of Science will be systematically searched. Forest plots will be used to estimate the associations between arginine and its related catabolic products with MDD. Subgroup analysis and meta-regression will also be performed to investigate the source of the potential heterogeneity. Sensitivity analysis will be performed to strengthen the results and to investigate whether any single study would have a significant effect on the results of meta-analysis. Publication bias will be tested for using the funnel plot with Begg test and Egger test. The Newcastle-Ottawa Scale will be applied to assess the risk of bias of observational studies. RESULTS: An integrated assessment of arginine with its related catabolic products may contribute to predict the risk of MDD. ETHICS AND DISSEMINATION: The results of associations between arginine with its related catabolic products and MDD will be reported in a peer-reviewed publication. With our findings from this meta-analysis, we hope to provide the most up-to-date evidence for the contributions of arginine and related catabolic products to predict the risk of MDD. SYSTEMATIC REVIEW REGISTRATION: The protocol of current meta-analysis has been registered at the Open Science Framework [Available at: https://doi.org/10.17605/osf.io/7fn59]. Wolters Kluwer Health 2020-07-02 /pmc/articles/PMC7337538/ /pubmed/32629736 http://dx.doi.org/10.1097/MD.0000000000021068 Text en Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5000
Cao, Bing
Deng, Runze
Wang, Dongfang
Li, Li
Ren, Zhongyu
Xu, Lixin
Gao, Xiao
Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway
title Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway
title_full Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway
title_fullStr Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway
title_full_unstemmed Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway
title_short Association between arginine catabolism and major depressive disorder: A protocol for the systematic review and meta-analysis of metabolic pathway
title_sort association between arginine catabolism and major depressive disorder: a protocol for the systematic review and meta-analysis of metabolic pathway
topic 5000
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337538/
https://www.ncbi.nlm.nih.gov/pubmed/32629736
http://dx.doi.org/10.1097/MD.0000000000021068
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