E. coli Rep helicase and RecA recombinase unwind G4 DNA and are important for resistance to G4-stabilizing ligands

G-quadruplex (G4) DNA structures can form physical barriers within the genome that must be unwound to ensure cellular genomic integrity. Here, we report unanticipated roles for the Escherichia coli Rep helicase and RecA recombinase in tolerating toxicity induced by G4-stabilizing ligands in vivo. We...

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Detalles Bibliográficos
Autores principales: Paul, Tapas, Voter, Andrew F, Cueny, Rachel R, Gavrilov, Momčilo, Ha, Taekjip, Keck, James L, Myong, Sua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337899/
https://www.ncbi.nlm.nih.gov/pubmed/32449930
http://dx.doi.org/10.1093/nar/gkaa442

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