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PolyA-miner: accurate assessment of differential alternative poly-adenylation from 3′Seq data using vector projections and non-negative matrix factorization

Almost 70% of human genes undergo alternative polyadenylation (APA) and generate mRNA transcripts with varying lengths, typically of the 3′ untranslated regions (UTR). APA plays an important role in development and cellular differentiation, and its dysregulation can cause neuropsychiatric diseases a...

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Detalles Bibliográficos
Autores principales:	Yalamanchili, Hari Krishna, Alcott, Callison E, Ji, Ping, Wagner, Eric J, Zoghbi, Huda Y, Liu, Zhandong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Methods Online
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337927/ https://www.ncbi.nlm.nih.gov/pubmed/32463457 http://dx.doi.org/10.1093/nar/gkaa398

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