Analyzing pre-symptomatic tissue to gain insights into the molecular and mechanistic origins of late-onset degenerative trinucleotide repeat disease

How genetic defects trigger the molecular changes that cause late-onset disease is important for understanding disease progression and therapeutic development. Fuchs’ endothelial corneal dystrophy (FECD) is an RNA-mediated disease caused by a trinucleotide CTG expansion in an intron within the TCF4...

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Detalles Bibliográficos
Autores principales: Chu, Yongjun, Hu, Jiaxin, Liang, Hanquan, Kanchwala, Mohammed, Xing, Chao, Beebe, Walter, Bowman, C Bradley, Gong, Xin, Corey, David R, Mootha, V Vinod
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337964/
https://www.ncbi.nlm.nih.gov/pubmed/32463444
http://dx.doi.org/10.1093/nar/gkaa422

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