Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management

Pharmacogenomic (PGx) testing aided by therapeutic drug monitoring (TDM) has the potential to improve medication-related outcomes in some individuals prescribed psychiatric medications. Many commonly prescribed psychiatric medications are metabolized through polymorphic drug metabolizing enzymes suc...

Descripción completa

Detalles Bibliográficos
Autores principales: Brown, Jacob T., Bishop, Jeffrey R., Schneiderhan, Mark E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: College of Psychiatric & Neurologic Pharmacists 2020
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337998/
https://www.ncbi.nlm.nih.gov/pubmed/32685338
http://dx.doi.org/10.9740/mhc.2020.07.254
_version_ 1783554589986914304
author Brown, Jacob T.
Bishop, Jeffrey R.
Schneiderhan, Mark E.
author_facet Brown, Jacob T.
Bishop, Jeffrey R.
Schneiderhan, Mark E.
author_sort Brown, Jacob T.
collection PubMed
description Pharmacogenomic (PGx) testing aided by therapeutic drug monitoring (TDM) has the potential to improve medication-related outcomes in some individuals prescribed psychiatric medications. Many commonly prescribed psychiatric medications are metabolized through polymorphic drug metabolizing enzymes such as cytochrome p450 (CYP) 2D6 (CYP2D6) and CYP2C19. Through PGx testing, clinicians can make biologically informed choices when selecting a new medication, and TDM may help inform dose adjustments or assess exposures to current treatments. Herein, we describe 2 complex case reports of individuals with multiple psychiatric diagnoses and extensive histories of medication failures who underwent PGx testing in addition to TDM as part of a pharmacist-led comprehensive medication therapy management evaluation in a community mental health clinic setting.
format Online
Article
Text
id pubmed-7337998
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher College of Psychiatric & Neurologic Pharmacists
record_format MEDLINE/PubMed
spelling pubmed-73379982020-07-16 Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management Brown, Jacob T. Bishop, Jeffrey R. Schneiderhan, Mark E. Ment Health Clin Case Reports Pharmacogenomic (PGx) testing aided by therapeutic drug monitoring (TDM) has the potential to improve medication-related outcomes in some individuals prescribed psychiatric medications. Many commonly prescribed psychiatric medications are metabolized through polymorphic drug metabolizing enzymes such as cytochrome p450 (CYP) 2D6 (CYP2D6) and CYP2C19. Through PGx testing, clinicians can make biologically informed choices when selecting a new medication, and TDM may help inform dose adjustments or assess exposures to current treatments. Herein, we describe 2 complex case reports of individuals with multiple psychiatric diagnoses and extensive histories of medication failures who underwent PGx testing in addition to TDM as part of a pharmacist-led comprehensive medication therapy management evaluation in a community mental health clinic setting. College of Psychiatric & Neurologic Pharmacists 2020-07-02 /pmc/articles/PMC7337998/ /pubmed/32685338 http://dx.doi.org/10.9740/mhc.2020.07.254 Text en © 2020 CPNP. The Mental Health Clinician is a publication of the College of Psychiatric and Neurologic Pharmacists. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License, which permits non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Brown, Jacob T.
Bishop, Jeffrey R.
Schneiderhan, Mark E.
Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
title Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
title_full Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
title_fullStr Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
title_full_unstemmed Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
title_short Using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
title_sort using pharmacogenomics and therapeutic drug monitoring to guide drug selection and dosing in outpatient mental health comprehensive medication management
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7337998/
https://www.ncbi.nlm.nih.gov/pubmed/32685338
http://dx.doi.org/10.9740/mhc.2020.07.254
work_keys_str_mv AT brownjacobt usingpharmacogenomicsandtherapeuticdrugmonitoringtoguidedrugselectionanddosinginoutpatientmentalhealthcomprehensivemedicationmanagement
AT bishopjeffreyr usingpharmacogenomicsandtherapeuticdrugmonitoringtoguidedrugselectionanddosinginoutpatientmentalhealthcomprehensivemedicationmanagement
AT schneiderhanmarke usingpharmacogenomicsandtherapeuticdrugmonitoringtoguidedrugselectionanddosinginoutpatientmentalhealthcomprehensivemedicationmanagement

Ejemplares similares