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Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics

Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects on centriole duplication and supernumerary cen...

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Detalles Bibliográficos
Autores principales:	Byrne, Dominic P., Clarke, Christopher J., Brownridge, Philip J., Kalyuzhnyy, Anton, Perkins, Simon, Campbell, Amy, Mason, David, Jones, Andrew R., Eyers, Patrick A., Eyers, Claire E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Chemical Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338032/ https://www.ncbi.nlm.nih.gov/pubmed/32501498 http://dx.doi.org/10.1042/BCJ20200309

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