PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

Inhibition of WEE1 kinase by AZD1775 has shown promising results in clinical cancer trials, but markers predicting AZD1775 response are lacking. Here we analysed AZD1775 response in a panel of human breast cancer (BC) cell lines by global proteome/transcriptome profiling and identified two groups of...

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Detalles Bibliográficos
Autores principales: Brunner, Andrä, Suryo Rahmanto, Aldwin, Johansson, Henrik, Franco, Marcela, Viiliäinen, Johanna, Gazi, Mohiuddin, Frings, Oliver, Fredlund, Erik, Spruck, Charles, Lehtiö, Janne, Rantala, Juha K, Larsson, Lars-Gunnar, Sangfelt, Olle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338058/
https://www.ncbi.nlm.nih.gov/pubmed/32628111
http://dx.doi.org/10.7554/eLife.57894

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