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Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin

In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X-ray phot...

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Autores principales: Kaya, S. Irem, Kurbanoglu, Sevinc, Yavuz, Ejmer, Demiroglu Mustafov, Sibel, Sen, Fatih, Ozkan, Sibel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338395/
https://www.ncbi.nlm.nih.gov/pubmed/32632278
http://dx.doi.org/10.1038/s41598-020-68055-6
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author Kaya, S. Irem
Kurbanoglu, Sevinc
Yavuz, Ejmer
Demiroglu Mustafov, Sibel
Sen, Fatih
Ozkan, Sibel A.
author_facet Kaya, S. Irem
Kurbanoglu, Sevinc
Yavuz, Ejmer
Demiroglu Mustafov, Sibel
Sen, Fatih
Ozkan, Sibel A.
author_sort Kaya, S. Irem
collection PubMed
description In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The mean particle size of the nanoparticles calculated by the TEM analysis was found to be 1.98 nm ± 0.29 nm, and the Ru nanoparticles were mostly dispersed on the support material. Glassy carbon electrode (GCE) surface was modified with Ruthenium/Vulcan carbon-based nanomaterials (Ru@VC), and characterization of the nanosensor was performed using electrochemical impedance spectroscopy and cyclic voltammetry. The limit of detection (LOD) and limit of quantification (LOQ) values were found as 9.25 × 10(–9) M and 2.8 × 10(–8) M in buffer samples. To demonstrate the applicability and validity of developed nanosensor, it was used for the determination of Idarubicin in Idamen(®) IV (10 mg/10 mL vial) and human serum sample. The results of recovery studies showed that the Ru@VC/GCE nanosensor was free from excipient interferences in the dosage forms of injection, and it can be successfully applied to biological samples.
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spelling pubmed-73383952020-07-07 Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin Kaya, S. Irem Kurbanoglu, Sevinc Yavuz, Ejmer Demiroglu Mustafov, Sibel Sen, Fatih Ozkan, Sibel A. Sci Rep Article In this work, a novel nanosensing platform was suggested based on ruthenium for the sensitive determination of Idarubicin anticancer drugs. Ruthenium/Vulcan carbon-based nanoparticles were synthesized ultrasonication method and then characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The mean particle size of the nanoparticles calculated by the TEM analysis was found to be 1.98 nm ± 0.29 nm, and the Ru nanoparticles were mostly dispersed on the support material. Glassy carbon electrode (GCE) surface was modified with Ruthenium/Vulcan carbon-based nanomaterials (Ru@VC), and characterization of the nanosensor was performed using electrochemical impedance spectroscopy and cyclic voltammetry. The limit of detection (LOD) and limit of quantification (LOQ) values were found as 9.25 × 10(–9) M and 2.8 × 10(–8) M in buffer samples. To demonstrate the applicability and validity of developed nanosensor, it was used for the determination of Idarubicin in Idamen(®) IV (10 mg/10 mL vial) and human serum sample. The results of recovery studies showed that the Ru@VC/GCE nanosensor was free from excipient interferences in the dosage forms of injection, and it can be successfully applied to biological samples. Nature Publishing Group UK 2020-07-06 /pmc/articles/PMC7338395/ /pubmed/32632278 http://dx.doi.org/10.1038/s41598-020-68055-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kaya, S. Irem
Kurbanoglu, Sevinc
Yavuz, Ejmer
Demiroglu Mustafov, Sibel
Sen, Fatih
Ozkan, Sibel A.
Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_full Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_fullStr Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_full_unstemmed Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_short Carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug Idarubicin
title_sort carbon-based ruthenium nanomaterial-based electroanalytical sensors for the detection of anticancer drug idarubicin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338395/
https://www.ncbi.nlm.nih.gov/pubmed/32632278
http://dx.doi.org/10.1038/s41598-020-68055-6
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