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How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients

Over the years, the practice of medicine has evolved from authority-based to experience-based to evidence-based with the introduction of the scientific process, clinical trials, and outcomes-based data analysis (Tebala GD. Int J Med Sci. 2018;15(12):1397-1405). The time required to perform the neces...

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Autores principales: Costa, Alessandro, Weinstein, Eric S., Sahoo, D. Ruby, Thompson, Stanley C., Faccincani, Roberto, Ragazzoni, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338398/
https://www.ncbi.nlm.nih.gov/pubmed/32613929
http://dx.doi.org/10.1017/dmp.2020.195
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author Costa, Alessandro
Weinstein, Eric S.
Sahoo, D. Ruby
Thompson, Stanley C.
Faccincani, Roberto
Ragazzoni, Luca
author_facet Costa, Alessandro
Weinstein, Eric S.
Sahoo, D. Ruby
Thompson, Stanley C.
Faccincani, Roberto
Ragazzoni, Luca
author_sort Costa, Alessandro
collection PubMed
description Over the years, the practice of medicine has evolved from authority-based to experience-based to evidence-based with the introduction of the scientific process, clinical trials, and outcomes-based data analysis (Tebala GD. Int J Med Sci. 2018;15(12):1397-1405). The time required to perform the necessary randomized controlled trials, a systematic literature review, and meta-analysis of these trials to then create, accept, promulgate, and educate the practicing clinicians to use the evidence-based clinical guidelines is typically measured in years. When the severe acute respiratory syndrome novel coronavirus-2 (SARS-nCoV-2) pandemic commenced in Wuhan, China at the end of 2019, there were few available clinical guidelines to deploy, let alone adapt and adopt to treat the surge of coronavirus disease 2019 (COVID-19) patients. The aim of this study is to first explain how clinical guidelines, on which bedside clinicians have grown accustomed, can be created in the midst of a pandemic, with an evolving scientific understanding of the pathophysiology of the hypercoagulable state. The second is to adapt and adopt current venous thromboembolism diagnostic and treatment guidelines, while relying on the limited available observational reporting of COVID-19 patients to create a comprehensive clinical guideline to treat COVID-19 patients.
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spelling pubmed-73383982020-07-07 How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients Costa, Alessandro Weinstein, Eric S. Sahoo, D. Ruby Thompson, Stanley C. Faccincani, Roberto Ragazzoni, Luca Disaster Med Public Health Prep Original Research Over the years, the practice of medicine has evolved from authority-based to experience-based to evidence-based with the introduction of the scientific process, clinical trials, and outcomes-based data analysis (Tebala GD. Int J Med Sci. 2018;15(12):1397-1405). The time required to perform the necessary randomized controlled trials, a systematic literature review, and meta-analysis of these trials to then create, accept, promulgate, and educate the practicing clinicians to use the evidence-based clinical guidelines is typically measured in years. When the severe acute respiratory syndrome novel coronavirus-2 (SARS-nCoV-2) pandemic commenced in Wuhan, China at the end of 2019, there were few available clinical guidelines to deploy, let alone adapt and adopt to treat the surge of coronavirus disease 2019 (COVID-19) patients. The aim of this study is to first explain how clinical guidelines, on which bedside clinicians have grown accustomed, can be created in the midst of a pandemic, with an evolving scientific understanding of the pathophysiology of the hypercoagulable state. The second is to adapt and adopt current venous thromboembolism diagnostic and treatment guidelines, while relying on the limited available observational reporting of COVID-19 patients to create a comprehensive clinical guideline to treat COVID-19 patients. Cambridge University Press 2020-06-16 /pmc/articles/PMC7338398/ /pubmed/32613929 http://dx.doi.org/10.1017/dmp.2020.195 Text en © Society for Disaster Medicine and Public Health, Inc. 2020 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Costa, Alessandro
Weinstein, Eric S.
Sahoo, D. Ruby
Thompson, Stanley C.
Faccincani, Roberto
Ragazzoni, Luca
How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients
title How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients
title_full How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients
title_fullStr How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients
title_full_unstemmed How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients
title_short How to Build the Plane While Flying: VTE/PE Thromboprophylaxis Clinical Guidelines for COVID-19 Patients
title_sort how to build the plane while flying: vte/pe thromboprophylaxis clinical guidelines for covid-19 patients
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338398/
https://www.ncbi.nlm.nih.gov/pubmed/32613929
http://dx.doi.org/10.1017/dmp.2020.195
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