Uncovering mutation-specific morphogenic phenotypes and paracrine-mediated vessel dysfunction in a biomimetic vascularized mammary duct platform

The mammary gland is a highly vascularized tissue capable of expansion and regression during development and disease. To enable mechanistic insight into the coordinated morphogenic crosstalk between the epithelium and vasculature, we introduce a 3D microfluidic platform that juxtaposes a human mamma...

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Detalles Bibliográficos
Autores principales: Kutys, Matthew L., Polacheck, William J., Welch, Michaela K., Gagnon, Keith A., Koorman, Thijs, Kim, Sudong, Li, Linqing, McClatchey, Andrea I., Chen, Christopher S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338408/
https://www.ncbi.nlm.nih.gov/pubmed/32632100
http://dx.doi.org/10.1038/s41467-020-17102-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338408/
https://www.ncbi.nlm.nih.gov/pubmed/32632100
http://dx.doi.org/10.1038/s41467-020-17102-x

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