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β-amyloid and tau drive early Alzheimer’s disease decline while glucose hypometabolism drives late decline

Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer’s disease (AD), suggesting that Aβ may not be the optimal target for treating AD. The evaluation of Aβ, tau, and neurodegenerative (A/T/N) biomarkers has been proposed for classify...

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Detalles Bibliográficos
Autores principales:	Hammond, Tyler C., Xing, Xin, Wang, Chris, Ma, David, Nho, Kwangsik, Crane, Paul K., Elahi, Fanny, Ziegler, David A., Liang, Gongbo, Cheng, Qiang, Yanckello, Lucille M., Jacobs, Nathan, Lin, Ai-Ling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338410/ https://www.ncbi.nlm.nih.gov/pubmed/32632135 http://dx.doi.org/10.1038/s42003-020-1079-x

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