Cargando…

Gα(12/13) signaling in metabolic diseases

As the key governors of diverse physiological processes, G protein-coupled receptors (GPCRs) have drawn attention as primary targets for several diseases, including diabetes and cardiovascular disease. Heterotrimeric G proteins converge signals from ~800 members of the GPCR family. Among the members...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Yoon Mee, Kuen, Da-Sol, Chung, Yeonseok, Kurose, Hitoshi, Kim, Sang Geon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338450/ https://www.ncbi.nlm.nih.gov/pubmed/32576930 http://dx.doi.org/10.1038/s12276-020-0454-5

Ejemplares similares

Critical regulation of follicular helper T cell differentiation and function by Gα(13) signaling
por: Kuen, Da-Sol, et al.
Publicado: (2021)

Autocrine TGF-β1 Maintains the Stability of Foxp3(+) Regulatory T Cells via IL-12Rβ2 Downregulation
por: Choi, Garam, et al.
Publicado: (2020)

IL-17-Producing Cells in Tumor Immunity: Friends or Foes?
por: Kuen, Da-Sol, et al.
Publicado: (2020)

Future prospects of immune checkpoint blockade in cancer: from response prediction to overcoming resistance
por: Park, Young-Jun, et al.
Publicado: (2018)

Gα(12) overexpressed in hepatocellular carcinoma reduces microRNA-122 expression via HNF4α inactivation, which causes c-Met induction
por: Yang, Yoon Mee, et al.
Publicado: (2015)

Gα(12) and Gα(13): Versatility in Physiology and Pathology
por: Guo, Paipai, et al.
Publicado: (2022)

Regulation of thymus-dependent and thymus-independent production of immunoglobulin G subclasses by Galpha(12 )and Galpha(13)
por: Lee, Song Jin, et al.
Publicado: (2008)

Gα12 regulates osteoclastogenesis by modulating NFATc1 expression
por: Song, Min‐Kyoung, et al.
Publicado: (2017)

G(12/13) Signaling Pathways Substitute for Integrin αIIbβ3-Signaling for Thromboxane Generation in Platelets
por: Bhavaraju, Kamala, et al.
Publicado: (2011)

The PAR2 inhibitor I-287 selectively targets Gα(q) and Gα(12/13) signaling and has anti-inflammatory effects
por: Avet, Charlotte, et al.
Publicado: (2020)

Overlap in signaling between Smoothened and the α subunit of the heterotrimeric G protein G(13)
por: Guo, Xueshui, et al.
Publicado: (2018)

Receptor selectivity between the G proteins Gα(12) and Gα(13) is defined by a single leucine-to-isoleucine variation
por: Mackenzie, Amanda E., et al.
Publicado: (2019)

Gα(12) overexpression in hepatocytes by ER stress exacerbates acute liver injury via ROCK1-mediated miR-15a and ALOX12 dysregulation
por: Tak, Jihoon, et al.
Publicado: (2022)

TYRO3 blockade enhances anti-PD-1 therapy response by modulating expression of CCN1 in tumor microenvironment
por: Park, Miso, et al.
Publicado: (2023)

Loss of G(α12/13) exacerbates apical area dependence of actomyosin contractility
por: Xie, Shicong, et al.
Publicado: (2016)

The emerging roles of Gα12/13 proteins on the hallmarks of cancer in solid tumors
por: Rasheed, Suhail Ahmed Kabeer, et al.
Publicado: (2021)

Essential roles of Gα(12/13) signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
por: Lin, Fang, et al.
Publicado: (2005)

G(i/o) Protein-Dependent and -Independent Actions of Pertussis Toxin (PTX)
por: Mangmool, Supachoke, et al.
Publicado: (2011)

Multiple functions of G protein-coupled receptor kinases
por: Watari, Kenji, et al.
Publicado: (2014)

Gastrin stimulates pancreatic cancer cell directional migration by activating the Gα12/13–RhoA–ROCK signaling pathway
por: Mu, Ganggang, et al.
Publicado: (2018)

Amphetamines signal through intracellular TAAR1 receptors coupled to Gα(13) and Gα(S) in discrete subcellular domains
por: Underhill, Suzanne M., et al.
Publicado: (2019)

Gα(12/13) regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
por: Lin, Fang, et al.
Publicado: (2009)

Sphingosine-1-Phosphate Enhances α(1)-Adrenergic Vasoconstriction via S1P2–G(12/13)–ROCK Mediated Signaling
por: Panta, Cecília R., et al.
Publicado: (2019)

Gα13 Mediates a Signal That Is Essential for Proliferation and Survival of Thymocyte Progenitors
por: McNeil Coffield, V., et al.
Publicado: (2004)

Naturally occurring hotspot cancer mutations in Gα(13) promote oncogenic signaling
por: Maziarz, Marcin, et al.
Publicado: (2021)

Cellular and Molecular Links between Autoimmunity and Lipid Metabolism
por: Ryu, Heeju, et al.
Publicado: (2019)

Knockout of Purinergic P2Y(6) Receptor Fails to Improve Liver Injury and Inflammation in Non-Alcoholic Steatohepatitis
por: Nishiyama, Kazuhiro, et al.
Publicado: (2023)

Loss of signaling via Gα13 in germinal center B cell-derived lymphoma
por: Muppidi, Jagan R., et al.
Publicado: (2014)

Drosophila Ric-8 interacts with the Gα(12/13) subunit, Concertina, during activation of the Folded gastrulation pathway
por: Peters, Kimberly A., et al.
Publicado: (2013)

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα(12/13) and RhoA
por: Ackerman, Sarah D., et al.
Publicado: (2015)

Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth
por: Ha, Ji Hee, et al.
Publicado: (2015)

Electrochemically driven stereoselective approach to syn-1,2-diol derivatives from vinylarenes and DMF
por: Chung, Da Sol, et al.
Publicado: (2021)

Molecular network of HCC aggressiveness
por: Kim, Sang Geon, et al.
Publicado: (2015)

Determinants at the N- and C-termini of Gα(12) required for activation of Rho-mediated signaling
por: Ritchie, Benjamin J, et al.
Publicado: (2013)

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis
por: Gan, Chai Phei, et al.
Publicado: (2014)

Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα(12/13)-Rho-Rac1 pathway
por: Li, Jing, et al.
Publicado: (2013)

Therapeutic Targets for Treatment of Heart Failure: Focus on GRKs and β-Arrestins Affecting βAR Signaling
por: Mangmool, Supachoke, et al.
Publicado: (2018)

New Therapeutics for Heart Failure: Focusing on cGMP Signaling
por: Mangmool, Supachoke, et al.
Publicado: (2023)

Metabolic engineering of Escherichia coli for the production of 1,3-diaminopropane, a three carbon diamine
por: Chae, Tong Un, et al.
Publicado: (2015)

Dysregulated Liver Metabolism and Polycystic Ovarian Syndrome
por: Khan, Muhammad Sohaib, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_2fiugo9q3qhlu7i9kmhd1ri1ii