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Proteomics-based screening of the target proteins associated with antidepressant-like effect and mechanism of nimesulide

Nimesulide is an inhibitor of COX-2 with antioxidant and anti-inflammatory effects. However, few studies have explored the antidepressant mechanism of nimesulide. Here, we evaluated the therapeutic effects of nimesulide on CUMS rats. iTRAQ technology was used to identify the differentially expressed...

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Detalles Bibliográficos
Autores principales: Luo, Wen, Luo, Ying, Yang, Junqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338510/
https://www.ncbi.nlm.nih.gov/pubmed/32632112
http://dx.doi.org/10.1038/s41598-020-66420-z