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Spermidine activates RIP1 deubiquitination to inhibit TNF-α-induced NF-κB/p65 signaling pathway in osteoarthritis

Spermidine has been known to inhibit the production of pro-inflammatory cytokines. However, there are no reports about anti-inflammatory effects of spermidine on osteoarthritis (OA). Herein, we examined whether OA progression could be delayed by intraperitoneal injection (i.p.) of spermidine in the...

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Detalles Bibliográficos
Autores principales:	Chen, Zhong, Lin, Chuang-Xin, Song, Bin, Li, Chang-Chuan, Qiu, Jun-Xiong, Li, Shi-Xun, Lin, Si-Peng, Luo, Wen-Qiang, Fu, Yuan, Fang, Gui-Bin, Wei-Ping, Li, Saw, Phei Er, Ding, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338517/ https://www.ncbi.nlm.nih.gov/pubmed/32632306 http://dx.doi.org/10.1038/s41419-020-2710-y

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