Effects of Thermally Induced Configuration Changes on rAAV Genome’s Enzymatic Accessibility

Physical titers for recombinant adeno-associated viral (rAAV) vectors are measured by quantifying viral genomes. It is generally perceived that AAV virions disassemble and release DNA upon thermal treatment. Here, we present data on enzymatic accessibility of rAAV genomes when AAV virions were subje...

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Detalles Bibliográficos
Autores principales: Xu, Yinxia, Guo, Ping, Zhang, Junping, Chrzanowski, Matthew, Chew, Helen, Firrman, Jenni A., Sang, Nianli, Diao, Yong, Xiao, Weidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338580/
https://www.ncbi.nlm.nih.gov/pubmed/32671135
http://dx.doi.org/10.1016/j.omtm.2020.06.005

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