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Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction
The apelin and Elabela proteins constitute a spatiotemporal double-ligand system that controls apelin receptor (APJ) signal transduction. Phosphorylation of multiple sites within the C-terminus of APJ is essential for the recruitment of β-arrestins. We sought to determine the precise mechanisms by w...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338617/ https://www.ncbi.nlm.nih.gov/pubmed/32863206 http://dx.doi.org/10.1016/j.redox.2020.101629 |