Cargando…

Default mode network connectivity is related to pain frequency and intensity in adolescents

Pain during adolescence is common and is associated with future pain chronicity and mental health in adulthood. However, understanding of the neural underpinnings of chronic pain has largely come from studies in adults, with recent studies in adolescents suggesting potentially unique neural features...

Descripción completa

Detalles Bibliográficos
Autores principales: Jones, Scott A., Morales, Angelica M., Holley, Amy L., Wilson, Anna C., Nagel, Bonnie J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338779/
https://www.ncbi.nlm.nih.gov/pubmed/32634754
http://dx.doi.org/10.1016/j.nicl.2020.102326
_version_ 1783554757839814656
author Jones, Scott A.
Morales, Angelica M.
Holley, Amy L.
Wilson, Anna C.
Nagel, Bonnie J.
author_facet Jones, Scott A.
Morales, Angelica M.
Holley, Amy L.
Wilson, Anna C.
Nagel, Bonnie J.
author_sort Jones, Scott A.
collection PubMed
description Pain during adolescence is common and is associated with future pain chronicity and mental health in adulthood. However, understanding of the neural underpinnings of chronic pain has largely come from studies in adults, with recent studies in adolescents suggesting potentially unique neural features during this vulnerable developmental period. In addition to alterations in the pain network, resting state functional magnetic resonance imaging studies in adults suggest alterations in the default mode network (DMN), involved in internally-driven, self-referential thought, may underlie chronic pain; however, these findings have yet to be examined in adolescents. The current study sought to investigate associations between pain frequency and intensity, and disruptions in DMN connectivity, in adolescents. Adolescents (ages 12–20) with varying levels of pain frequency and intensity, recruited from a pediatric pain clinic and the local community (n = 86; 60% female), underwent resting state functional magnetic resonance imaging. Using independent components analysis, the DMN was identified and correlated voxel-wise to assess associations between pain frequency and intensity and DMN connectivity. Findings revealed that adolescents with greater pain frequency demonstrated greater DMN to superior frontal gyrus connectivity, while adolescents with greater pain intensity demonstrated lesser DMN to cerebellum (lobule VIII) connectivity, during rest. These findings suggest that increasing levels of pain are associated with potential desegregation of the DMN and the prefrontal cortex, important for cognitive control, and with novel patterns of DMN to cerebellum connectivity. These findings may prove beneficial as neurobiological targets for future treatment efforts in adolescents.
format Online
Article
Text
id pubmed-7338779
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-73387792020-07-14 Default mode network connectivity is related to pain frequency and intensity in adolescents Jones, Scott A. Morales, Angelica M. Holley, Amy L. Wilson, Anna C. Nagel, Bonnie J. Neuroimage Clin Regular Article Pain during adolescence is common and is associated with future pain chronicity and mental health in adulthood. However, understanding of the neural underpinnings of chronic pain has largely come from studies in adults, with recent studies in adolescents suggesting potentially unique neural features during this vulnerable developmental period. In addition to alterations in the pain network, resting state functional magnetic resonance imaging studies in adults suggest alterations in the default mode network (DMN), involved in internally-driven, self-referential thought, may underlie chronic pain; however, these findings have yet to be examined in adolescents. The current study sought to investigate associations between pain frequency and intensity, and disruptions in DMN connectivity, in adolescents. Adolescents (ages 12–20) with varying levels of pain frequency and intensity, recruited from a pediatric pain clinic and the local community (n = 86; 60% female), underwent resting state functional magnetic resonance imaging. Using independent components analysis, the DMN was identified and correlated voxel-wise to assess associations between pain frequency and intensity and DMN connectivity. Findings revealed that adolescents with greater pain frequency demonstrated greater DMN to superior frontal gyrus connectivity, while adolescents with greater pain intensity demonstrated lesser DMN to cerebellum (lobule VIII) connectivity, during rest. These findings suggest that increasing levels of pain are associated with potential desegregation of the DMN and the prefrontal cortex, important for cognitive control, and with novel patterns of DMN to cerebellum connectivity. These findings may prove beneficial as neurobiological targets for future treatment efforts in adolescents. Elsevier 2020-06-25 /pmc/articles/PMC7338779/ /pubmed/32634754 http://dx.doi.org/10.1016/j.nicl.2020.102326 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Jones, Scott A.
Morales, Angelica M.
Holley, Amy L.
Wilson, Anna C.
Nagel, Bonnie J.
Default mode network connectivity is related to pain frequency and intensity in adolescents
title Default mode network connectivity is related to pain frequency and intensity in adolescents
title_full Default mode network connectivity is related to pain frequency and intensity in adolescents
title_fullStr Default mode network connectivity is related to pain frequency and intensity in adolescents
title_full_unstemmed Default mode network connectivity is related to pain frequency and intensity in adolescents
title_short Default mode network connectivity is related to pain frequency and intensity in adolescents
title_sort default mode network connectivity is related to pain frequency and intensity in adolescents
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338779/
https://www.ncbi.nlm.nih.gov/pubmed/32634754
http://dx.doi.org/10.1016/j.nicl.2020.102326
work_keys_str_mv AT jonesscotta defaultmodenetworkconnectivityisrelatedtopainfrequencyandintensityinadolescents
AT moralesangelicam defaultmodenetworkconnectivityisrelatedtopainfrequencyandintensityinadolescents
AT holleyamyl defaultmodenetworkconnectivityisrelatedtopainfrequencyandintensityinadolescents
AT wilsonannac defaultmodenetworkconnectivityisrelatedtopainfrequencyandintensityinadolescents
AT nagelbonniej defaultmodenetworkconnectivityisrelatedtopainfrequencyandintensityinadolescents