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Efficient Multiplex Genome Editing in Streptomyces via Engineered CRISPR-Cas12a Systems

Streptomyces strains produce a great number of valuable natural products. With the development of genome sequencing, a vast number of biosynthetic gene clusters with high potential for use in the discovery of valuable clinical drugs have been revealed. Therefore, emerging needs for tools to manipula...

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Detalles Bibliográficos
Autores principales:	Zhang, Jun, Zhang, Dan, Zhu, Jie, Liu, Huayi, Liang, Shufang, Luo, Yunzi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Bioengineering and Biotechnology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338789/ https://www.ncbi.nlm.nih.gov/pubmed/32695773 http://dx.doi.org/10.3389/fbioe.2020.00726

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