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Influences of preoperative metformin on immunological factors in early breast cancer
PURPOSE: Metformin has been suggested to possibly reduce cancer risk. However, the mechanism underlying the positive effects of metformin on cancer treatment remains unclear. We conducted a prospective study to evaluate the effects of preoperative metformin in patients with early breast cancer. METH...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338817/ https://www.ncbi.nlm.nih.gov/pubmed/32533334 http://dx.doi.org/10.1007/s00280-020-04092-2 |
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author | Tsukioki, Takahiro Shien, Tadahiko Tanaka, Takehiro Suzuki, Yoko Kajihara, Yukiko Hatono, Minami Kawada, Kengo Kochi, Mariko Iwamoto, Takayuki Ikeda, Hirokuni Taira, Naruto Doihara, Hiroyoshi Toyooka, Shinichi |
author_facet | Tsukioki, Takahiro Shien, Tadahiko Tanaka, Takehiro Suzuki, Yoko Kajihara, Yukiko Hatono, Minami Kawada, Kengo Kochi, Mariko Iwamoto, Takayuki Ikeda, Hirokuni Taira, Naruto Doihara, Hiroyoshi Toyooka, Shinichi |
author_sort | Tsukioki, Takahiro |
collection | PubMed |
description | PURPOSE: Metformin has been suggested to possibly reduce cancer risk. However, the mechanism underlying the positive effects of metformin on cancer treatment remains unclear. We conducted a prospective study to evaluate the effects of preoperative metformin in patients with early breast cancer. METHOD: We evaluated the effects on immunological factors (TILs, CD4 + , CD8 + , PD-L1, IFNγ and IL-2) by comparing core needle biopsies (CNB) obtained before metformin treatment with surgical specimens. Seventeen patients were enrolled in this prospective study from January to December 2016. We also analyzed 59 patients undergoing surgery during the same period to reveal the correlation of immune factors between CNB and surgical specimen. RESULT: There was a moderate correlation between CNB and surgical specimens on TILs and CD8 + lymphocyte. (TILs Rs = 0.63, CD4 + Rs = 0.224, CD8 + Rs = 0.42) In the metformin group, TILs increases were confirmed in five (29%) patients, while a decrease was confirmed in two (12%). The expressions of CD4 + and CD8 + by TILs were increased in 41% and 18% of surgical specimens, respectively. However, TILs number (p = 0.0554), CD4+ (p = 0.0613) and CD8 + (p = 0.0646) expressions did not significantly increased. Furthermore, IFNγ expression appeared to be increased in response to metformin (p = 0.08). CONCLUSION: Preoperative metformin tends to increase TILs, as well as the numbers of CD4 and CD8 positive lymphocytes, and IFNγ levels. Metformin might improve immune function and have a possibility of chemo-sensitivity and thereby increase the effectiveness of immunotherapy, based on the results of this preliminary study. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00280-020-04092-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7338817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-73388172020-07-09 Influences of preoperative metformin on immunological factors in early breast cancer Tsukioki, Takahiro Shien, Tadahiko Tanaka, Takehiro Suzuki, Yoko Kajihara, Yukiko Hatono, Minami Kawada, Kengo Kochi, Mariko Iwamoto, Takayuki Ikeda, Hirokuni Taira, Naruto Doihara, Hiroyoshi Toyooka, Shinichi Cancer Chemother Pharmacol Original Article PURPOSE: Metformin has been suggested to possibly reduce cancer risk. However, the mechanism underlying the positive effects of metformin on cancer treatment remains unclear. We conducted a prospective study to evaluate the effects of preoperative metformin in patients with early breast cancer. METHOD: We evaluated the effects on immunological factors (TILs, CD4 + , CD8 + , PD-L1, IFNγ and IL-2) by comparing core needle biopsies (CNB) obtained before metformin treatment with surgical specimens. Seventeen patients were enrolled in this prospective study from January to December 2016. We also analyzed 59 patients undergoing surgery during the same period to reveal the correlation of immune factors between CNB and surgical specimen. RESULT: There was a moderate correlation between CNB and surgical specimens on TILs and CD8 + lymphocyte. (TILs Rs = 0.63, CD4 + Rs = 0.224, CD8 + Rs = 0.42) In the metformin group, TILs increases were confirmed in five (29%) patients, while a decrease was confirmed in two (12%). The expressions of CD4 + and CD8 + by TILs were increased in 41% and 18% of surgical specimens, respectively. However, TILs number (p = 0.0554), CD4+ (p = 0.0613) and CD8 + (p = 0.0646) expressions did not significantly increased. Furthermore, IFNγ expression appeared to be increased in response to metformin (p = 0.08). CONCLUSION: Preoperative metformin tends to increase TILs, as well as the numbers of CD4 and CD8 positive lymphocytes, and IFNγ levels. Metformin might improve immune function and have a possibility of chemo-sensitivity and thereby increase the effectiveness of immunotherapy, based on the results of this preliminary study. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00280-020-04092-2) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-06-12 2020 /pmc/articles/PMC7338817/ /pubmed/32533334 http://dx.doi.org/10.1007/s00280-020-04092-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Tsukioki, Takahiro Shien, Tadahiko Tanaka, Takehiro Suzuki, Yoko Kajihara, Yukiko Hatono, Minami Kawada, Kengo Kochi, Mariko Iwamoto, Takayuki Ikeda, Hirokuni Taira, Naruto Doihara, Hiroyoshi Toyooka, Shinichi Influences of preoperative metformin on immunological factors in early breast cancer |
title | Influences of preoperative metformin on immunological factors in early breast cancer |
title_full | Influences of preoperative metformin on immunological factors in early breast cancer |
title_fullStr | Influences of preoperative metformin on immunological factors in early breast cancer |
title_full_unstemmed | Influences of preoperative metformin on immunological factors in early breast cancer |
title_short | Influences of preoperative metformin on immunological factors in early breast cancer |
title_sort | influences of preoperative metformin on immunological factors in early breast cancer |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7338817/ https://www.ncbi.nlm.nih.gov/pubmed/32533334 http://dx.doi.org/10.1007/s00280-020-04092-2 |
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