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Modeling and analysis of site-specific mutations in cancer identifies known plus putative novel hotspots and bias due to contextual sequences
In cancer, recurrently mutated sites in DNA and proteins, called hotspots, are thought to be raised by positive selection and therefore important due to its potential functional impact. Although recent evidence for APOBEC enzymatic activity have shown that specific types of sequences are likely to b...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Research Network of Computational and Structural Biotechnology
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339035/ https://www.ncbi.nlm.nih.gov/pubmed/32670506 http://dx.doi.org/10.1016/j.csbj.2020.06.022 |