Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis

Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each of these cell types is uncertain. Through sequential screens, we...

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Detalles Bibliográficos
Autores principales: Heaton, George R., Landeck, Natalie, Mamais, Adamantios, Nalls, Mike A., Nixon-Abell, Jonathon, Kumaran, Ravindran, Beilina, Alexandra, Pellegrini, Laura, Li, Yan, Harvey, Kirsten, Cookson, Mark R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339134/
https://www.ncbi.nlm.nih.gov/pubmed/32434048
http://dx.doi.org/10.1016/j.nbd.2020.104948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339134/
https://www.ncbi.nlm.nih.gov/pubmed/32434048
http://dx.doi.org/10.1016/j.nbd.2020.104948

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