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Post‐mortem tissue donation programs as platforms to accelerate cancer research
Given recent advances in the treatment of cancer, patients are surviving longer but frequently develop treatment‐resistant and inoperable metastases. Biomedical research has advanced to the stage where in‐depth study of these lesions is feasible, with the goal of further refining our understanding o...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339213/ https://www.ncbi.nlm.nih.gov/pubmed/32198850 http://dx.doi.org/10.1002/cjp2.159 |
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author | Dankner, Matthew Issa‐Chergui, Badia Bouganim, Nathaniel |
author_facet | Dankner, Matthew Issa‐Chergui, Badia Bouganim, Nathaniel |
author_sort | Dankner, Matthew |
collection | PubMed |
description | Given recent advances in the treatment of cancer, patients are surviving longer but frequently develop treatment‐resistant and inoperable metastases. Biomedical research has advanced to the stage where in‐depth study of these lesions is feasible, with the goal of further refining our understanding of metastatic dissemination, therapeutic resistance and inoperable tumors. However, there is a lack of tissue specimens derived from multiple metastatic sites within the same patient that would permit the study of these processes. Furthermore, patients with rapidly progressing or metastatic disease are rarely candidates for surgery, making those most in need of innovation and discovery extremely difficult to study. For this reason, post‐mortem tissue donation programs are an approach that is quickly gaining traction in the cancer research community. Herein, we discuss what post‐mortem tissue donation entails, attitudes towards these procedures, and highlight important studies already utilizing these resources. In addition, we propose future directions for use of this tissue that can directly improve clinical management of advanced cancer patients. |
format | Online Article Text |
id | pubmed-7339213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-73392132020-07-13 Post‐mortem tissue donation programs as platforms to accelerate cancer research Dankner, Matthew Issa‐Chergui, Badia Bouganim, Nathaniel J Pathol Clin Res Perspective Given recent advances in the treatment of cancer, patients are surviving longer but frequently develop treatment‐resistant and inoperable metastases. Biomedical research has advanced to the stage where in‐depth study of these lesions is feasible, with the goal of further refining our understanding of metastatic dissemination, therapeutic resistance and inoperable tumors. However, there is a lack of tissue specimens derived from multiple metastatic sites within the same patient that would permit the study of these processes. Furthermore, patients with rapidly progressing or metastatic disease are rarely candidates for surgery, making those most in need of innovation and discovery extremely difficult to study. For this reason, post‐mortem tissue donation programs are an approach that is quickly gaining traction in the cancer research community. Herein, we discuss what post‐mortem tissue donation entails, attitudes towards these procedures, and highlight important studies already utilizing these resources. In addition, we propose future directions for use of this tissue that can directly improve clinical management of advanced cancer patients. John Wiley & Sons, Inc. 2020-03-21 /pmc/articles/PMC7339213/ /pubmed/32198850 http://dx.doi.org/10.1002/cjp2.159 Text en © 2020 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Perspective Dankner, Matthew Issa‐Chergui, Badia Bouganim, Nathaniel Post‐mortem tissue donation programs as platforms to accelerate cancer research |
title | Post‐mortem tissue donation programs as platforms to accelerate cancer research |
title_full | Post‐mortem tissue donation programs as platforms to accelerate cancer research |
title_fullStr | Post‐mortem tissue donation programs as platforms to accelerate cancer research |
title_full_unstemmed | Post‐mortem tissue donation programs as platforms to accelerate cancer research |
title_short | Post‐mortem tissue donation programs as platforms to accelerate cancer research |
title_sort | post‐mortem tissue donation programs as platforms to accelerate cancer research |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339213/ https://www.ncbi.nlm.nih.gov/pubmed/32198850 http://dx.doi.org/10.1002/cjp2.159 |
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