Cargando…

Clostridium perfringens epsilon toxin binds to erythrocyte MAL receptors and triggers phosphatidylserine exposure

Epsilon toxin (ETX) is a 33‐kDa pore‐forming toxin produced by type B and D strains of Clostridium perfringens. We previously found that ETX caused haemolysis of human red blood cells, but not of erythrocytes from other species. The cellular and molecular mechanisms of ETX‐mediated haemolysis are no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geng, Zhijun, Huang, Jing, Kang, Lin, Gao, Shan, Yuan, Yuan, Li, Yanwei, Wang, Jing, Xin, Wenwen, Wang, Jinglin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339222/ https://www.ncbi.nlm.nih.gov/pubmed/32463157 http://dx.doi.org/10.1111/jcmm.15315

Ejemplares similares

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors
por: Gao, Jie, et al.
Publicado: (2018)

Systematic evaluation of membrane-camouflaged nanoparticles in neutralizing Clostridium perfringens ε-toxin
por: Xu, Jinglin, et al.
Publicado: (2023)

The pore structure of Clostridium perfringens epsilon toxin
por: Savva, Christos G., et al.
Publicado: (2019)

Is Clostridium perfringens epsilon toxin associated with multiple sclerosis?
por: Titball, Richard W, et al.
Publicado: (2023)

Immunization with a novel Clostridium perfringens epsilon toxin mutant rETX(Y196E)-C confers strong protection in mice
por: Yao, Wenwu, et al.
Publicado: (2016)

Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis
por: Wagley, Sariqa, et al.
Publicado: (2018)

Clostridium perfringens epsilon toxin induces blood brain barrier permeability via caveolae-dependent transcytosis and requires expression of MAL
por: Linden, Jennifer R., et al.
Publicado: (2019)

Evidence for a Prepore Stage in the Action of Clostridium perfringens Epsilon Toxin
por: Robertson, Susan L., et al.
Publicado: (2011)

Clostridium perfringens Epsilon Toxin: A Malevolent Molecule for Animals and Man?
por: Stiles, Bradley G., et al.
Publicado: (2013)

Lung endothelial cells are sensitive to epsilon toxin from Clostridium perfringens
por: Dorca-Arévalo, Jonatan, et al.
Publicado: (2020)

Clostridium perfringens Epsilon Toxin Binds to and Kills Primary Human Lymphocytes
por: Shetty, Samantha V., et al.
Publicado: (2023)

Oligomerization of Clostridium perfringens Epsilon Toxin Is Dependent upon Caveolins 1 and 2
por: Fennessey, Christine M., et al.
Publicado: (2012)

Clostridium perfringens Epsilon Toxin Increases the Small Intestinal Permeability in Mice and Rats
por: Goldstein, Jorge, et al.
Publicado: (2009)

Mapping of the continuous epitopes displayed on the Clostridium perfringens type D epsilon-toxin
por: Alves, Guilherme Guerra, et al.
Publicado: (2017)

PLGA Nanoparticle-Based Dissolving Microneedle Vaccine of Clostridium perfringens ε Toxin
por: Wan, Wei, et al.
Publicado: (2023)

Proteolytic Processing and Activation of Clostridium perfringens Epsilon Toxin by Caprine Small Intestinal Contents
por: Freedman, John C., et al.
Publicado: (2014)

Correction: Clostridium perfringens Epsilon Toxin Increases the Small Intestinal Permeability in Mice and Rats
por: Goldstein, Jorge, et al.
Publicado: (2013)

Pathology and Pathogenesis of Brain Lesions Produced by Clostridium perfringens Type D Epsilon Toxin
por: Finnie, John W., et al.
Publicado: (2022)

The Myelin and Lymphocyte Protein MAL Is Required for Binding and Activity of Clostridium perfringens ε-Toxin
por: Rumah, Kareem Rashid, et al.
Publicado: (2015)

Clostridium perfringens Epsilon Toxin Targets Granule Cells in the Mouse Cerebellum and Stimulates Glutamate Release
por: Lonchamp, Etienne, et al.
Publicado: (2010)

Clostridium Perfringens Epsilon Toxin Binds to Membrane Lipids and Its Cytotoxic Action Depends on Sulfatide
por: Gil, Carles, et al.
Publicado: (2015)

Recombinant Alpha, Beta, and Epsilon Toxins of Clostridium perfringens: Production Strategies and Applications as Veterinary Vaccines
por: Ferreira, Marcos Roberto A., et al.
Publicado: (2016)

Clostridium perfringens Epsilon Toxin Compromises the Blood-Brain Barrier in a Humanized Zebrafish Model
por: Adler, Drew, et al.
Publicado: (2019)

Clostridium perfringens epsilon toxin H149A mutant as a platform for receptor binding studies
por: Bokori-Brown, Monika, et al.
Publicado: (2013)

Clostridium perfringens Epsilon Toxin Causes Selective Death of Mature Oligodendrocytes and Central Nervous System Demyelination
por: Linden, Jennifer R., et al.
Publicado: (2015)

Clostridium perfringens epsilon toxin vaccine candidate lacking toxicity to cells expressing myelin and lymphocyte protein
por: Morcrette, Helen, et al.
Publicado: (2019)

Epsilon Toxin from Clostridium perfringens Causes Inhibition of Potassium inward Rectifier (Kir) Channels in Oligodendrocytes
por: Bossu, Jean Louis, et al.
Publicado: (2020)

Immunization with recombinant fusion of LTB and linear epitope (40–62) of epsilon toxin elicits protective immune response against the epsilon toxin of Clostridium perfringens type D
por: Kaushik, Himani, et al.
Publicado: (2019)

Correlation between In Vitro Cytotoxicity and In Vivo Lethal Activity in Mice of Epsilon Toxin Mutants from Clostridium perfringens
por: Dorca-Arévalo, Jonatan, et al.
Publicado: (2014)

Immunogenicity of a Trivalent Recombinant Vaccine Against Clostridium perfringens Alpha, Beta, and Epsilon Toxins in Farm Ruminants
por: Moreira, Gustavo Marçal Schmidt Garcia, et al.
Publicado: (2016)

Oral Multiple Sclerosis Drugs Inhibit the In vitro Growth of Epsilon Toxin Producing Gut Bacterium, Clostridium perfringens
por: Rumah, Kareem R., et al.
Publicado: (2017)

Immunogenicity assessment of Clostridium perfringens type D epsilon toxin epitope-based chimeric construct in mice and rabbit
por: Singh, Ajay Pratap, et al.
Publicado: (2020)

New Mutants of Epsilon Toxin from Clostridium perfringens with an Altered Receptor-Binding Site and Cell-Type Specificity
por: Dorca-Arévalo, Jonatan, et al.
Publicado: (2022)

Epsilon toxin–producing Clostridium perfringens colonize the multiple sclerosis gut microbiome overcoming CNS immune privilege
por: Ma, Yinghua, et al.
Publicado: (2023)

A Novel Panel of Rabbit Monoclonal Antibodies and Their Diverse Applications Including Inhibition of Clostridium perfringens Epsilon Toxin Oligomerization
por: Linden, Jennifer R., et al.
Publicado: (2018)

Recombinant expression of in silico identified Bcell epitope of epsilon toxin of Clostridium perfringens in translational fusion with a carrier protein
por: Kaushik, Himani, et al.
Publicado: (2013)

Clostridium perfringens Epsilon-Toxin Impairs the Barrier Function in MDCK Cell Monolayers in a Ca(2+)-Dependent Manner
por: Nagahama, Masahiro, et al.
Publicado: (2020)

Regulation of Toxin Production in Clostridium perfringens
por: Ohtani, Kaori, et al.
Publicado: (2016)

Sialidases Affect the Host Cell Adherence and Epsilon Toxin-Induced Cytotoxicity of Clostridium perfringens Type D Strain CN3718
por: Li, Jihong, et al.
Publicado: (2011)

Interaction of Clostridium perfringens Epsilon Toxin with the Plasma Membrane: The Role of Amino Acids Y42, Y43 and H162
por: Marshall, Skye, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_gq9h75sofk8ud9nkc734294h6r