Donor-derived Cell-free DNA in Infections in Kidney Transplant Recipients: Case Series

BACKGROUND. Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive plasma biomarker to evaluate for transplant allograft rejection. The relationship between infectious complications in kidney allografts and dd-cfDNA has received cursory attention in prior publications. METHODS. Retrospective review...

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Detalles Bibliográficos
Autores principales: Goussous, Naeem, Xie, Wen, Dawany, Noor, Scalea, Joseph R., Bartosic, Amanda, Haririan, Abdolreza, Kalil, Roberto, Drachenberg, Cinthia, Costa, Nadiesda, Weir, Matthew R., Bromberg, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Kidney Transplantation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339327/
https://www.ncbi.nlm.nih.gov/pubmed/32766423
http://dx.doi.org/10.1097/TXD.0000000000001019
Descripción
Sumario:BACKGROUND. Donor-derived cell-free DNA (dd-cfDNA) is a noninvasive plasma biomarker to evaluate for transplant allograft rejection. The relationship between infectious complications in kidney allografts and dd-cfDNA has received cursory attention in prior publications. METHODS. Retrospective review of all renal transplant recipients who underwent dd-cfDNA testing between November 2017 and August 2019. RESULTS. We report on 7 cases in whom infections affecting the transplanted kidney were associated with elevation in dd-cfDNA without concomitant rejection or elevation in serum creatinine. Five patients had BK viremia, and 2 patients had urinary tract infection associated with elevated dd-cfDNA levels. CONCLUSIONS. These observations suggest that elevations in dd-cfDNA are not specific to kidney allograft rejection and can be associated with infections affecting the transplanted kidney. This biomarker may be valuable in evaluating infectious complications of kidney allografts.

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