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Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation

Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a...

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Autores principales: Gbesemete, D., Barker, M., Lawrence, W. T., Watson, D., de Graaf, H., Read, R. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339437/
https://www.ncbi.nlm.nih.gov/pubmed/32635912
http://dx.doi.org/10.1186/s12916-020-01670-2
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author Gbesemete, D.
Barker, M.
Lawrence, W. T.
Watson, D.
de Graaf, H.
Read, R. C.
author_facet Gbesemete, D.
Barker, M.
Lawrence, W. T.
Watson, D.
de Graaf, H.
Read, R. C.
author_sort Gbesemete, D.
collection PubMed
description Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. This raises complex questions about the social and ethical acceptability of risk to individuals, given the potential benefit to the wider population, and as such, a study cannot be done without public involvement. We conducted a structured public consultation with 57 individuals aged 20–40 years to understand public attitudes to a CHIM, and pre-requisites for enrolment. The overall response to this strategy was positive, and many would volunteer altruistically. Carefully controlled infection is viewed as safer than natural exposure to wild virus. The prolonged social isolation required for the proposed CHIM is considered an obstacle but not insurmountable, with reasonable compensation and supportive care. Given the significant level of public interest, a CHIM should be done as open science with regular, controlled dissemination of information into the public domain. Importantly, there was a strong view that the final decision whether to conduct a CHIM should be in the hands of qualified and experienced clinician-scientists and the authorities.
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spelling pubmed-73394372020-07-09 Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation Gbesemete, D. Barker, M. Lawrence, W. T. Watson, D. de Graaf, H. Read, R. C. BMC Med Correspondence Rapid development of an effective vaccine for SARSCoV2 is a global priority. A controlled human infection model (CHIM) would accelerate the efficacy assessment of candidate vaccines. This strategy would require deliberate exposure of volunteers to SARSCoV2 with no currently available treatment and a small but definite risk of serious illness or death. This raises complex questions about the social and ethical acceptability of risk to individuals, given the potential benefit to the wider population, and as such, a study cannot be done without public involvement. We conducted a structured public consultation with 57 individuals aged 20–40 years to understand public attitudes to a CHIM, and pre-requisites for enrolment. The overall response to this strategy was positive, and many would volunteer altruistically. Carefully controlled infection is viewed as safer than natural exposure to wild virus. The prolonged social isolation required for the proposed CHIM is considered an obstacle but not insurmountable, with reasonable compensation and supportive care. Given the significant level of public interest, a CHIM should be done as open science with regular, controlled dissemination of information into the public domain. Importantly, there was a strong view that the final decision whether to conduct a CHIM should be in the hands of qualified and experienced clinician-scientists and the authorities. BioMed Central 2020-07-07 /pmc/articles/PMC7339437/ /pubmed/32635912 http://dx.doi.org/10.1186/s12916-020-01670-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Correspondence
Gbesemete, D.
Barker, M.
Lawrence, W. T.
Watson, D.
de Graaf, H.
Read, R. C.
Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation
title Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation
title_full Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation
title_fullStr Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation
title_full_unstemmed Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation
title_short Exploring the acceptability of controlled human infection with SARSCoV2—a public consultation
title_sort exploring the acceptability of controlled human infection with sarscov2—a public consultation
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339437/
https://www.ncbi.nlm.nih.gov/pubmed/32635912
http://dx.doi.org/10.1186/s12916-020-01670-2
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