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Age-dependent alterations in the immunoreactivity of macrophage inflammatory protein-3α and its receptor CCR6 in the gerbil hippocampus
Neuroinflammation is a primary characteristic of the aging brain. During normal aging, macrophage inflammatory protein-3α (MIP-3α) and its receptor C-C chemokine receptor type 6 (CCR6) serve pivotal roles in the neuroinflammatory process in the brain. The aim of the present study was to investigate...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339448/ https://www.ncbi.nlm.nih.gov/pubmed/32627009 http://dx.doi.org/10.3892/mmr.2020.11216 |
Sumario: | Neuroinflammation is a primary characteristic of the aging brain. During normal aging, macrophage inflammatory protein-3α (MIP-3α) and its receptor C-C chemokine receptor type 6 (CCR6) serve pivotal roles in the neuroinflammatory process in the brain. The aim of the present study was to investigate age-dependent alterations in the immunoreactivity of MIP-3α and CCR6 in the gerbil hippocampus at postnatal month (PM) 1, 6, 12 and 24 via immunohistochemistry. In the PM 1 group, both MIP-3α and CCR6 immunoreactivity were observed primarily in the stratum pyramidale in the hippocampus proper and in the granule cell layer in the dentate gyrus. In the PM 6 and PM 12 groups, MIP-3α in the stratum pyramidale and granule cell layer was decreased compared with the PM 1 group, and CCR6 immunoreactivity in both layers was faint. In the PM 24 group, MIP-3α expression in the stratum pyramidale and granule cell layer was higher than that in the PM 1 group, and CCR6 immunoreactivity in both layers was increased compared with the PM 12 group; however, it was decreased compared with the PM 1 group. In conclusion, MIP-3α and CCR6 immunoreactivity were altered in the hippocampus during normal aging. The results of the current study suggested that age-dependent alterations of MIP-3α and CCR6 may be associated with age-related neuroinflammation in the hippocampus. |
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