Pre-existing immunity to SARS-CoV-2: the knowns and unknowns

T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T c...

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Detalles Bibliográficos
Autores principales: Sette, Alessandro, Crotty, Shane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339790/
https://www.ncbi.nlm.nih.gov/pubmed/32636479
http://dx.doi.org/10.1038/s41577-020-0389-z
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author Sette, Alessandro
Crotty, Shane
author_facet Sette, Alessandro
Crotty, Shane
author_sort Sette, Alessandro
collection PubMed
description T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses.
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spelling pubmed-73397902020-07-07 Pre-existing immunity to SARS-CoV-2: the knowns and unknowns Sette, Alessandro Crotty, Shane Nat Rev Immunol Comment T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess their association with COVID-19 disease severity and vaccine responses. Nature Publishing Group UK 2020-07-07 2020 /pmc/articles/PMC7339790/ /pubmed/32636479 http://dx.doi.org/10.1038/s41577-020-0389-z Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Comment
Sette, Alessandro
Crotty, Shane
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
title Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
title_full Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
title_fullStr Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
title_full_unstemmed Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
title_short Pre-existing immunity to SARS-CoV-2: the knowns and unknowns
title_sort pre-existing immunity to sars-cov-2: the knowns and unknowns
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339790/
https://www.ncbi.nlm.nih.gov/pubmed/32636479
http://dx.doi.org/10.1038/s41577-020-0389-z
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