Cargando…

Chemopreventive Agents in Oral Premalignancy: A Medical Management Review

AIMS AND OBJECTIVE: The term chemoprevention denotes the use of specific natural or synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the process of carcinogen activation and prevent the conversion of preneoplastic cells. These agents play an active role in the seco...

Descripción completa

Detalles Bibliográficos
Autores principales: Suvarna, Chintada, Chaitanya, Nallan CSK, Ameer, Shaik, Inamdar, Pavitra, Alugubelli, Swetha, Bhagyanagar, Alakananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339999/
https://www.ncbi.nlm.nih.gov/pubmed/32670899
http://dx.doi.org/10.4103/jispcd.JISPCD_424_19
_version_ 1783554973604249600
author Suvarna, Chintada
Chaitanya, Nallan CSK
Ameer, Shaik
Inamdar, Pavitra
Alugubelli, Swetha
Bhagyanagar, Alakananda
author_facet Suvarna, Chintada
Chaitanya, Nallan CSK
Ameer, Shaik
Inamdar, Pavitra
Alugubelli, Swetha
Bhagyanagar, Alakananda
author_sort Suvarna, Chintada
collection PubMed
description AIMS AND OBJECTIVE: The term chemoprevention denotes the use of specific natural or synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the process of carcinogen activation and prevent the conversion of preneoplastic cells. These agents play an active role in the secondary level of prevention and reduce malignancy-associated morbidity and mortality. A new term, “prophylactic antioxidant therapy,” was coined and proposed. This review has assessed all major chemopreventive agents used for oral premalignancy and malignant conditions, which will reduce the economic burden on the patients. MATERIALS AND METHODS: A systematic literature search was performed using PubMed, Medline, Embase, Cochrane Library, and EBSCO search, with language restriction to English. The search incorporated published literature from 1990 to 2018 using the medical subject heading terms. Literature search was performed using the following keywords: Chemoprevention, Premalignancy, and Oral Malignancy. RESULTS: Of 99 publications related to the search strategy, 45 full articles relevant to the chemopreventive agents in premalignacy and oral malignancy were acquired for further inspection. Of the 45 articles, 30 met the inclusion criteria. Data were collected, and a brief summary of the studies regarding different chemopreventive agents that were most commonly used in oral premalignancy and malignancies was written. CONCLUSION: This review suggests administration of major chemopreventive agents for superior prognosis in individuals with an elevated risk of premalignancy and malignancy.
format Online
Article
Text
id pubmed-7339999
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-73399992020-07-14 Chemopreventive Agents in Oral Premalignancy: A Medical Management Review Suvarna, Chintada Chaitanya, Nallan CSK Ameer, Shaik Inamdar, Pavitra Alugubelli, Swetha Bhagyanagar, Alakananda J Int Soc Prev Community Dent Review Articles AIMS AND OBJECTIVE: The term chemoprevention denotes the use of specific natural or synthetic chemical agents to prevent carcinogenesis. Chemoprevention may help delay the process of carcinogen activation and prevent the conversion of preneoplastic cells. These agents play an active role in the secondary level of prevention and reduce malignancy-associated morbidity and mortality. A new term, “prophylactic antioxidant therapy,” was coined and proposed. This review has assessed all major chemopreventive agents used for oral premalignancy and malignant conditions, which will reduce the economic burden on the patients. MATERIALS AND METHODS: A systematic literature search was performed using PubMed, Medline, Embase, Cochrane Library, and EBSCO search, with language restriction to English. The search incorporated published literature from 1990 to 2018 using the medical subject heading terms. Literature search was performed using the following keywords: Chemoprevention, Premalignancy, and Oral Malignancy. RESULTS: Of 99 publications related to the search strategy, 45 full articles relevant to the chemopreventive agents in premalignacy and oral malignancy were acquired for further inspection. Of the 45 articles, 30 met the inclusion criteria. Data were collected, and a brief summary of the studies regarding different chemopreventive agents that were most commonly used in oral premalignancy and malignancies was written. CONCLUSION: This review suggests administration of major chemopreventive agents for superior prognosis in individuals with an elevated risk of premalignancy and malignancy. Wolters Kluwer - Medknow 2020-04-02 /pmc/articles/PMC7339999/ /pubmed/32670899 http://dx.doi.org/10.4103/jispcd.JISPCD_424_19 Text en Copyright: © 2020 Journal of International Society of Preventive and Community Dentistry http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Articles
Suvarna, Chintada
Chaitanya, Nallan CSK
Ameer, Shaik
Inamdar, Pavitra
Alugubelli, Swetha
Bhagyanagar, Alakananda
Chemopreventive Agents in Oral Premalignancy: A Medical Management Review
title Chemopreventive Agents in Oral Premalignancy: A Medical Management Review
title_full Chemopreventive Agents in Oral Premalignancy: A Medical Management Review
title_fullStr Chemopreventive Agents in Oral Premalignancy: A Medical Management Review
title_full_unstemmed Chemopreventive Agents in Oral Premalignancy: A Medical Management Review
title_short Chemopreventive Agents in Oral Premalignancy: A Medical Management Review
title_sort chemopreventive agents in oral premalignancy: a medical management review
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7339999/
https://www.ncbi.nlm.nih.gov/pubmed/32670899
http://dx.doi.org/10.4103/jispcd.JISPCD_424_19
work_keys_str_mv AT suvarnachintada chemopreventiveagentsinoralpremalignancyamedicalmanagementreview
AT chaitanyanallancsk chemopreventiveagentsinoralpremalignancyamedicalmanagementreview
AT ameershaik chemopreventiveagentsinoralpremalignancyamedicalmanagementreview
AT inamdarpavitra chemopreventiveagentsinoralpremalignancyamedicalmanagementreview
AT alugubelliswetha chemopreventiveagentsinoralpremalignancyamedicalmanagementreview
AT bhagyanagaralakananda chemopreventiveagentsinoralpremalignancyamedicalmanagementreview