Cargando…

The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female App(NL-G-F) mice over time demonstrate that progressive amyloid-b accumulation accelerates two main activated microglia states that are also present during normal aging. A...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frigerio, Carlo Sala, Wolfs, Leen, Fattorelli, Nicola, Thrupp, Nicola, Voytyuk, Iryna, Schmidt, Inga, Mancuso, Renzo, Chen, Wei-Ting, Woodbury, Maya E., Srivastava, Gyan, Möller, Thomas, Hudry, Eloise, Das, Sudeshna, Saido, Takaomi, Karran, Eric, Hyman, Bradley, Perry, V. Hugh, Fiers, Mark, De Strooper, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340153/ https://www.ncbi.nlm.nih.gov/pubmed/31018141 http://dx.doi.org/10.1016/j.celrep.2019.03.099

Ejemplares similares

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans
por: Thrupp, Nicola, et al.
Publicado: (2020)

Novel Alzheimer risk genes determine the microglia response to amyloid‐β but not to TAU pathology
por: Sierksma, Annerieke, et al.
Publicado: (2020)

microRNA-132 regulates gene expression programs involved in microglial homeostasis
por: Walgrave, Hannah, et al.
Publicado: (2023)

The Role of Microglia in Prion Diseases: A Paradigm of Functional Diversity
por: Obst, Juliane, et al.
Publicado: (2017)

Microglia and CD206(+) border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease
por: Wu, Xiaoting, et al.
Publicado: (2021)

BACE2 distribution in major brain cell types and identification of novel substrates
por: Voytyuk, Iryna, et al.
Publicado: (2018)

RNA Aptamer Probes as Optical Imaging Agents for the Detection of Amyloid Plaques
por: Farrar, Christian T., et al.
Publicado: (2014)

Knock-in models related to Alzheimer’s disease: synaptic transmission, plaques and the role of microglia
por: Benitez, Diana P., et al.
Publicado: (2021)

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old App(NL/NL) Knock-In Mice
por: Salas, Isabel H., et al.
Publicado: (2018)

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior
por: Ho, Hinze, et al.
Publicado: (2023)

AAV‐mediated delivery of an anti‐BACE1 VHH alleviates pathology in an Alzheimer's disease model
por: Marino, Marika, et al.
Publicado: (2022)

MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
por: Balusu, Sriram, et al.
Publicado: (2023)

Metabolism of amyloid β peptide and pathogenesis of Alzheimer’s disease
por: SAIDO, Takaomi C.
Publicado: (2013)

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
por: Clayton, Kevin, et al.
Publicado: (2021)

Correction to: Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
por: Clayton, Kevin, et al.
Publicado: (2021)

Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease
por: Vicente-Rodríguez, Marta, et al.
Publicado: (2023)

Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer’s Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin
por: Liu, Xiao, et al.
Publicado: (2021)

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer’s disease
por: Sobue, Akira, et al.
Publicado: (2021)

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP(NL-F/NL-F) knock-in mice
por: Shah, Disha, et al.
Publicado: (2018)

Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and APOE in Alzheimer’s Disease
por: Das, Sudeshna, et al.
Publicado: (2023)

APP mouse models for Alzheimer's disease preclinical studies
por: Sasaguri, Hiroki, et al.
Publicado: (2017)

APOE4 derived from astrocytes leads to blood–brain barrier impairment
por: Jackson, Rosemary J, et al.
Publicado: (2021)

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide
por: Nilsson, Per, et al.
Publicado: (2014)

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease
por: Hashimoto, Shoko, et al.
Publicado: (2018)

Neuroinflammation in mouse models of Alzheimer's disease
por: Saito, Takashi, et al.
Publicado: (2018)

Integrated Expression Profiles of mRNA and miRNA in Polarized Primary Murine Microglia
por: Freilich, Robert W., et al.
Publicado: (2013)

Prion protein in Alzheimer's pathogenesis: a hot and controversial issue
por: Benilova, Iryna, et al.
Publicado: (2010)

Efficient Gene Transfer to the Central Nervous System by Single-Stranded Anc80L65
por: Hudry, Eloise, et al.
Publicado: (2018)

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition
por: Pasciuto, Emanuela, et al.
Publicado: (2020)

Endothelial Cells Are Heterogeneous in Different Brain Regions and Are Dramatically Altered in Alzheimer's Disease
por: Bryant, Annie, et al.
Publicado: (2023)

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9
por: Dashkoff, Jonathan, et al.
Publicado: (2016)

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons
por: Pigoni, Martina, et al.
Publicado: (2016)

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease
por: Chávez-Gutiérrez, Lucía, et al.
Publicado: (2012)

The Multifarious Role of Microglia in Brain Metastasis
por: Soto, Manuel Sarmiento, et al.
Publicado: (2018)

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer’s Disease
por: Chen, Lingxuan, et al.
Publicado: (2018)

Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer’s disease
por: Islam, Anam, et al.
Publicado: (2023)

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model
por: Rice, Heather C., et al.
Publicado: (2020)

In Vivo Two Photon Imaging of Astrocytic Structure and Function in Alzheimer’s Disease
por: Kelly, Patricia, et al.
Publicado: (2018)

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease
por: Muñoz-Castro, Clara, et al.
Publicado: (2022)

Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer’s disease
por: Shah, Disha, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_9fqs0ln7j57t7n3f4gmnvvdqjf