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The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

Gene expression profiles of more than 10,000 individual microglial cells isolated from cortex and hippocampus of male and female App(NL-G-F) mice over time demonstrate that progressive amyloid-b accumulation accelerates two main activated microglia states that are also present during normal aging. A...

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Detalles Bibliográficos
Autores principales:	Frigerio, Carlo Sala, Wolfs, Leen, Fattorelli, Nicola, Thrupp, Nicola, Voytyuk, Iryna, Schmidt, Inga, Mancuso, Renzo, Chen, Wei-Ting, Woodbury, Maya E., Srivastava, Gyan, Möller, Thomas, Hudry, Eloise, Das, Sudeshna, Saido, Takaomi, Karran, Eric, Hyman, Bradley, Perry, V. Hugh, Fiers, Mark, De Strooper, Bart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340153/ https://www.ncbi.nlm.nih.gov/pubmed/31018141 http://dx.doi.org/10.1016/j.celrep.2019.03.099

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