Detection and Severity Assessment of Peripheral Occlusive Artery Disease via Deep Learning Analysis of Arterial Pulse Waveforms: Proof-of-Concept and Potential Challenges

Toward the ultimate goal of affordable and non-invasive screening of peripheral occlusive artery disease (PAD), the objective of this work is to investigate the potential of deep learning-based arterial pulse waveform analysis in detecting and assessing the severity of PAD. Using an established transmission line model of arterial hemodynamics, a large number of virtual patients associated with PAD of a wide range of severity and the corresponding arterial pulse waveform data were created. A deep convolutional neural network capable of detecting and assessing the severity of PAD based on the analysis of brachial and ankle arterial pulse waveforms was constructed, evaluated for efficacy, and compared with the state-of-the-art ankle-brachial index (ABI) using the virtual patients. The results suggested that deep learning may diagnose PAD more accurately and robustly than ABI. In sum, this work demonstrates the initial proof-of-concept of deep learning-based arterial pulse waveform analysis for affordable and convenient PAD screening as well as presents challenges that must be addressed for real-world clinical applications.