Dynamics of coagulopathy in patients with different COVID-19 severity

With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal of our present study was to evaluate which component of clot formation process including endothelial function, platelets aggregation and plasma coagulation,...

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Detalles Bibliográficos
Autores principales: Kalinskaya, Anna, Dukhin, Oleg, Molodtsov, Ivan, Maltseva, Alexandra, Sokorev, Denis, Elizarova, Antonina, Sapozhnikova, Olga, Glebova, Ksenia, Stonogina, Daria, Shakhidzhanov, Soslan, Nikonov, Evgeniy, Mazus, Alexey, Spiridonov, Ilia, Ataullakhanov, Fazly, Margolis, Leonid, Shpektor, Alexander, Vasilieva, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340199/
https://www.ncbi.nlm.nih.gov/pubmed/32637973
http://dx.doi.org/10.1101/2020.07.02.20145284
Descripción
Sumario:With the progress of COVID-19 studies, it became evident that SARS-CoV-2 infection is often associated with thrombotic complications. The goal of our present study was to evaluate which component of clot formation process including endothelial function, platelets aggregation and plasma coagulation, as well as endogenous fibrinolysis in patients with COVID-19 correlates with the severity of the disease. We prospectively included 58 patients with COVID-19 and 47 healthy volunteers as a control group that we recruited before the pandemic started. It turns out that plasma coagulation with subsequent platelet aggregation, but not endothelial function, correlates with the severity of the COVID-19. IL-6 blockade may play a beneficial role in COVID-19 induced coagulopathy.

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